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Esophageal Cancer clinical trials in Cleveland, OH

10 studies for Esophageal Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Louis Stokes Cleveland VA Medical Center, Cleveland
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

RecruitingPhase 3
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Recruiting
  • University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06263088

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

RecruitingObservational studyHealthy volunteers welcome
  • University Hospitals of Cleveland, Cleveland
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT00288119

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Esophageal Cancer

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

More about Esophageal Cancer on MedlinePlus

Esophageal Cancer trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.