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Liver Cancer (Hepatocellular Carcinoma) clinical trials in Chicago, IL

16 studies for Liver Cancer (Hepatocellular Carcinoma) are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #26, Chicago
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

National Liver Cancer Screening Trial

RecruitingPhase 4
  • Northwestern University, Chicago
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06084234

Defining the Ablative Dose for Y-90 TARE

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07586046

Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

RecruitingObservational study
  • RUSH University Medical Center, Chicago
  • University of Chicago, Chicago
Ages 22 and older · All sexes · Updated Sep 11, 2026 · NCT06486454

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06921785

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Lurie Children's Hospital-Chicago, Chicago
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

RecruitingPhase 3
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07166406

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

RecruitingPhase 2
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT05168163

Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

RecruitingPhase 1/2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT07042919

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

RecruitingPhase 1
  • Clinical Trial Site, Chicago
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT06600321

Therasphere® and Systemic Therapy for Patients With Hepatocellular Carcinoma That is High-risk

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT05620771

Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

RecruitingPhase 4
  • University of Chicago Medical Center, Chicago
Ages 18 to 64 · All sexes · Updated Jan 22, 2026 · NCT04373564

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

The Dragon PLC Trial (DRAGON-PLC)

Recruiting
  • Rush University Medical Center, Chicago
Ages 18 and older · All sexes · Updated May 15, 2025 · NCT06914648

Liver Cancer (Hepatocellular Carcinoma) trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.