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Metastatic Cancer clinical trials in Cleveland, OH
30 studies for Metastatic Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.
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BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)
RecruitingPhase 1/2
- Avenzo Therapeutics Recruiting Site, Cleveland
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
RecruitingPhase 2
- Case Western Reserve University, Cleveland
- UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
- UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor · 22 mi away
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
- University Hospitals Cleveland Medical Center, Cleveland
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- The Cleveland Clinic Taussig Cancer Center, Cleveland
A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
RecruitingPhase 1
- University Hospitals Cleveland Medical Center, Cleveland
- Cleveland Clinic, Cleveland
A Study of ASP3082 in Adults With Advanced Solid Tumors
RecruitingPhase 1
- Case Western, Cleveland
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
RecruitingPhase 2/3
- University Hospitals Cleveland Medical Center, Cleveland
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
RecruitingPhase 3
- Research Site, Cleveland
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
- Fairview Hospital, Cleveland
- Cleveland Clinic, Cleveland
- and 1 more
SLV-154 Treatment of Advanced Cancers
RecruitingPhase 1
- University Hospitals Cleveland Medical Center, Cleveland
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
- Fairview Hospital, Cleveland
- Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12 mi away
Study of ISM6331 in Participants With Advanced/Metastatic Mesothelioma or Other Advanced Solid Tumors
RecruitingPhase 1/2
- University Hospitals Cleveland Medical Center, Cleveland
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
RecruitingPhase 3
- Cleveland Clinic, Cleveland
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
RecruitingPhase 1
- Cleveland Clinic, Cleveland
A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors
RecruitingPhase 1
- Cleveland Clinic, Cleveland
FOG-001 in Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- University Hospitals Cleveland Medical Center, Seidman Cancer Center, Cleveland
- Cleveland Clinic, Cleveland
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
RecruitingPhase 3
- Research Site, Cleveland
- Research Site, Cleveland
A Study of ASP1002 in Adults for Treatment of Solid Tumors
RecruitingPhase 1
- University Hospitals of Cleveland, Cleveland
REMASTer: REcurrent Brain Metastases After SRS Trial
Recruiting
- Cleveland Clinic, Cleveland
First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- Research Site, Cleveland
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
RecruitingPhase 1
- University Hospitals - UH Cleveland Medical Center, Cleveland
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
RecruitingPhase 2/3
- Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen
RecruitingPhase 3
- Cleveland Clinic, Cleveland
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
RecruitingPhase 1
- University Hospitals Cleveland Medical Center, Cleveland
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of BC3195 in Patients With Advanced or Metastatic Cancer
RecruitingPhase 1
- Case Western Reserve University, Cleveland
Metastatic Cancer trials in other cities
- Houston, TX104 studies
- New York City, NY93 studies
- Nashville, TN70 studies
- Boston, MA63 studies
- Los Angeles, CA57 studies
- St. Louis, MO54 studies
- Arlington, VA53 studies
- Philadelphia, PA46 studies
- Chicago, IL45 studies
- San Antonio, TX44 studies
- Washington, DC43 studies
- Dallas, TX42 studies
Other studies in Cleveland
- Non-Small Cell Lung Cancer43 studies
- Cancer (all types)36 studies
- Breast Cancer35 studies
- Prostate Cancer34 studies
- Heart Failure33 studies
- Ovarian Cancer30 studies
- Lung Cancer26 studies
- Colorectal Cancer24 studies
- Cardiovascular Disease22 studies
- Endometrial Cancer20 studies
- Acute Myeloid Leukemia20 studies
- Crohn's Disease19 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.