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Metastatic Cancer clinical trials in Dallas, TX

42 studies for Metastatic Cancer are looking for participants at sites in and around Dallas (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • UT Southwestern/Simmons Cancer Center-Dallas, Dallas
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • UT Southwest Simmons Cancer Center, Dallas
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

RecruitingPhase 1
  • Texas Oncology, Dallas
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06234605

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • UT Southwestern, Dallas
Ages 19 and older · All sexes · Updated Oct 1, 2026 · NCT06586957

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • SCRI at Mary Crowley, Dallas
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

RecruitingPhase 2/3
  • Texas Oncology- Baylor Charles A. Sammons Cancer Center, Dallas
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06943755

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

RecruitingPhase 1/2
  • The University of Texas Southwestern Medical Center - Harold C Simmons Comprehensive Cancer Center, Dallas
Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas
  • University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital, Dallas
  • University of Texas Southwestern Medical Center-Zale Lipshy University Hospital, Dallas
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

A Study of NEOK001, a B7-H3 and ROR1 Targeting Bispecific ADC in Participants With Select Solid Tumors

RecruitingPhase 1
  • NEXT Oncology, Dallas
  • SCRI at Mary Crowley, Dallas
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07612176

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Texas Oncology - DFW, Dallas
  • Texas Oncology - DFW, Dallas
  • Texas Oncology - DFW, Dallas
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • Texas Oncology - DFW (Sammons CC), Dallas
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • UT Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

RecruitingPhase 3
  • Parkland Health and Hospital System, Dallas
  • UT Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07218380

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Parkland Health and Hospital System, Dallas
  • USO - Texas Oncology, Dallas
  • UT Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

RecruitingPhase 1/2
  • University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas
  • University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital, Dallas
  • University of Texas Southwestern Simmons Cancer Center - Redbird, Dallas
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07227415

CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Clinical Study Site, Dallas
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07335497

A Study of KK2269 in Adult Participants With Solid Tumors

RecruitingPhase 1
  • The University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06266299

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Dallas
Ages 18 to 75 · All sexes · Updated Sep 4, 2026 · NCT07038343

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas
  • Mary Crowley Cancer Research, Dallas
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07029399

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • University of Texas Southwestern, Dallas
  • Texas Oncology, P.A, Dallas
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Mary Crowley Cancer Research, Dallas
  • Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

A Study of ASP1002 in Adults for Treatment of Solid Tumors

RecruitingPhase 1
  • Mary Crowley Cancer Research Center, Dallas
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT05719558

A Study of PYX-201 in Advanced Solid Tumors

RecruitingPhase 1
  • NEXT Dallas, Dallas
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT05720117

Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung

RecruitingEarly phase 1
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT06712745

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

RecruitingPhase 3
  • Old Parkland Hospital Hematology Oncology Clinic, Dallas
  • UT Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06216301

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute at Mary Crowley, Dallas
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • Sarah Cannon Research Institute at Mary Crowley, Dallas
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Mary Crowley Cancer Research, Dallas
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

RecruitingPhase 1/2
  • Next Oncology, Dallas
  • UTSW Medical Center, Dallas
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT05735080

A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • NEXT Dallas, Dallas
Ages 18 and older · All sexes · Updated Mar 20, 2026 · NCT05948865

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • NEXT Oncology - Dallas, Dallas
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Mary Crowley Cancer Research, Dallas
  • Baylor University Medical Center, Dallas
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

RecruitingPhase 1
  • Urology Clinics of North Texas, Dallas
Ages 18 and older · Men · Updated Feb 4, 2026 · NCT04729114

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Texas Oncology - Baylor Charles A Sammons Cancer Center, Dallas
Ages 18 and older · All sexes · Updated Dec 16, 2025 · NCT06108050

Radiotherapy in Combination With Checkpoint Inhibition for Patients With Metastatic Kidney Cancer

RecruitingPhase 2
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Nov 12, 2025 · NCT06601296

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Dallas
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

RecruitingPhase 1/2
  • Mary Crowley Cancer Research, Dallas
Ages 18 and older · All sexes · Updated Aug 17, 2025 · NCT05394103

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

RecruitingPhase 1
  • Texas Oncology, Dallas
Ages 18 and older · All sexes · Updated Jul 1, 2025 · NCT06415487

Metastatic Cancer trials in other cities

Other studies in Dallas

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.