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Heart Failure clinical trials in Dallas, TX

42 studies for Heart Failure are looking for participants at sites in and around Dallas (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

RecruitingPhase 2/3
  • Children's Health-The Heart Center ( Site 0015), Dallas
29 Days – 17 Years · All sexes · Updated Nov 13, 2026 · NCT05714085

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Texas Health Research and Education Institute, Dallas
  • Southwest Family Medicine Associates, Dallas
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06424288

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Texas Health Research and Education Institute, Dallas
  • Southwest Family Medicine Associates, Dallas
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06935370

INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

Recruiting
  • Medical City Heart Hospital Dallas, Dallas
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT06965504

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Baylor University Hospital, Dallas
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06526195

Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes

Recruiting
  • UT Southwestern Medical Center, Dallas
All ages · All sexes · Updated Nov 5, 2026 · NCT06593314

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • Dallas, Dallas
All ages · All sexes · Updated Nov 4, 2026 · NCT00271180

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • Baylor University Medical Center, Dallas
  • The University of Texas Southwestern Medical Center, Dallas
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT06736574

ELEVATE-HFpEF Clinical Study

Recruiting
  • Dallas VA Medical Center, Dallas
Ages 40 and older · All sexes · Updated Nov 3, 2026 · NCT06678841

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Cedar Health Research, LLC, Dallas
Ages 18 to 99 · All sexes · Updated Oct 29, 2026 · NCT07037459

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

RecruitingPhase 3
  • Children's Medical Center Dallas - Cardiology, Dallas
Up to age 18 · All sexes · Updated Oct 27, 2026 · NCT07192952

Cardiogenic Shock Working Group Registry

RecruitingObservational study
  • Baylor Scott & White Advanced Heart Failure Clinic, Dallas
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT04682483

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • Baylor Scott and White Research Institute, Dallas
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT05064709

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Dallas
Ages 40 and older · All sexes · Updated Oct 21, 2026 · NCT06677060

NORM-HF Pivotal Study

Recruiting
  • Baylor Scott & White - Dallas, Dallas
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07574593

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 18, Dallas
Ages 30 to 84 · All sexes · Updated Oct 13, 2026 · NCT07795814

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Dallas
  • Research Site, Dallas
  • Research Site, Dallas
Ages 18 to 130 · All sexes · Updated Oct 13, 2026 · NCT06307652

CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

Recruiting
  • VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
Ages 60 and older · All sexes · Updated Oct 7, 2026 · NCT05996328

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

RecruitingPhase 2
  • University of Texas Southwestern Medical Center, Dallas
Ages 40 to 84 · All sexes · Updated Oct 5, 2026 · NCT06979362

NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

Recruiting
  • University of Texas Southwestern Medical Center, Dallas
  • Parkland Health & Hospital System (PHHS), Dallas
  • Baylor Scott and White - Health System, Dallas
All ages · All sexes · Updated Sep 29, 2026 · NCT06593327

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
  • Research Site, Dallas
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)

Recruiting
  • University of Texas Southwestern Medical Center - Clinical Heart and Vascular Center - West Campus Building 3 Location, Dallas
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07222813

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Dallas, TX Investigative Site 10042, Dallas
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

RecruitingPhase 2
  • University of Texas Southwestern Medical Center, Dallas, Dallas
Ages 40 to 85 · All sexes · Updated Aug 27, 2026 · NCT06793371

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

RecruitingObservational study
  • North Texas Cardiology Center, Dallas
  • Baylor Scott & White Research Institute, Dallas
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05489705

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Renal Disease Research Institute, Dallas
  • Texas Health Heart and Vascular Specialists, Dallas
  • Southwest Family Medicine_Dallas, Dallas
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • UT Southwestern, Dallas
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

RecruitingObservational study
  • Baylor University Medical Center, Dallas
Ages 18 to 99 · All sexes · Updated Aug 11, 2026 · NCT06939751

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

RecruitingPhase 2
  • Children's Health Dallas, Dallas
Ages 0 to 16 · All sexes · Updated Aug 10, 2026 · NCT06080074

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • Medical City Healthcare Dallas, Dallas
  • Baylor Scott & White -Dallas, Dallas
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Home-based Cardiac Rehabilitation in Heart Failure

RecruitingPhase 3
  • University of Texas Southwestern Medical Center, Dallas
  • Baylor Scott and White Health System, Dallas
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06349941

IEEM-Heat and Heart Failure

RecruitingHealthy volunteers welcome
  • Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas, Dallas
Ages 45 and older · All sexes · Updated May 26, 2026 · NCT06961929

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

RecruitingPhase 3
  • University of Texas Southwestern, Dallas
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

Recruiting
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070

Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

RecruitingPhase 2
  • UT Southwestern Medical Center, Dallas
Ages 50 and older · All sexes · Updated Feb 27, 2026 · NCT06130059

Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

RecruitingPhase 2
  • Baylor University Medical Center, Dallas
Ages 18 to 90 · All sexes · Updated Jan 22, 2026 · NCT03383419

Cardiopulmonary Stress Testing (CPET) AlloSure Study

RecruitingObservational study
  • Baylor Scott & White health research institute, Dallas
Ages 18 and older · All sexes · Updated Jan 22, 2026 · NCT04656080

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

RecruitingPhase 2/3
  • VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
Ages 18 and older · All sexes · Updated Dec 15, 2025 · NCT04982419

Get With The Guidelines-Heart Failure Registry

RecruitingObservational studyHealthy volunteers welcome
  • Amy Bennett, Dallas
Ages 18 to 125 · All sexes · Updated Jan 29, 2025 · NCT02693509

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

RecruitingObservational study
  • UT Southwestern Medical Center, Dallas
Ages 20 to 90 · All sexes · Updated Aug 22, 2024 · NCT01258231

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

RecruitingPhase 1/2
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 to 80 · All sexes · Updated Mar 26, 2024 · NCT04703842

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Dallas

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.