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Breast Cancer clinical trials in San Francisco, CA

43 studies for Breast Cancer are looking for participants at sites in and around San Francisco (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, San Francisco
Ages 18 to 130 · All sexes · Updated Oct 5, 2026 · NCT05417594

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06982521

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • Kaiser Permanente-San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, San Francisco
  • Clinical Trial Site, San Francisco
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Kaiser Permanente, San Francisco
  • UCSF Medical Center at Mission Bay, San Francisco
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

RecruitingHealthy volunteers welcome
  • University of California San Francisco, San Francisco
Ages 30 to 74 · Women · Updated Sep 21, 2026 · NCT02620852

Pulsed Electric Field Ablation for Metastatic Breast Cancer

Recruiting
  • University of California San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07487844

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • UCSF Zuckerberg SF General, San Francisco
  • University of California, San Francisco (UCSF), San Francisco
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

RecruitingPhase 1
  • UCSF Medical Center at Mission Bay, San Francisco
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT05307705

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

RecruitingPhase 1/2
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT05315700

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of California-San Fransisco, San Francisco
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07287917

Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

RecruitingObservational study
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05964504

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • California Pacific Medical Center-Pacific Campus, San Francisco
  • Kaiser Permanente-San Francisco, San Francisco
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

RecruitingPhase 2
  • University of San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06533826

ATEMPT 2.0: Adjuvant T-DM1 vs TH

RecruitingPhase 2
  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT04893109

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

RecruitingPhase 2
  • University of California San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT06518057

Generative AI Patient Education Module for Breast Oncology

Recruiting
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07512271

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

RecruitingPhase 3
  • University of California San Francisco - Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 to 100 · All sexes · Updated Aug 6, 2026 · NCT05232916

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Kaiser Permanente-San Francisco, San Francisco
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • UCSF Medical Center at Mission Bay, San Francisco
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844

Magnetic Resonance Imaging in Radiotherapy for Breast Cancer

RecruitingObservational study
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05902507

Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial

RecruitingPhase 3
  • University of California at San Francisco, San Francisco
Ages 18 to 50 · Women · Updated Jun 4, 2026 · NCT03011684

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • University of California San Francisco (UCSF), San Francisco
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

RecruitingPhase 2
  • UCSF Medical Center-Mission Bay/Benioff Children's Hospital, San Francisco
Ages 18 and older · Women · Updated May 6, 2026 · NCT03990896

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

RecruitingPhase 2
  • University of California San Francisco, San Francisco
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT04434040

Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

Recruiting
  • Zuckerberg San Francisco General, San Francisco
  • Kaiser Foundation Research Institute, San Francisco
  • University of San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Apr 30, 2026 · NCT05297734

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • California Pacific Medical Center-Pacific Campus, San Francisco
  • Kaiser Permanente-San Francisco, San Francisco
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Novel Body Composition Measurements in Association With Outcomes of Breast Reconstruction Reconstruction

RecruitingObservational study
  • University of California, San Francisco
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07546331

Microbiome and Association With Implant Infections

RecruitingPhase 2
  • University of California, San Francisco, San Francisco
Ages 18 and older · Women · Updated Mar 18, 2026 · NCT05020574

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Kaiser Permanente-San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

RecruitingPhase 2
  • University of California San Francisco (Data collection only), San Francisco
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT06099769

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

RecruitingPhase 1/2
  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT07145255

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of California San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International VErsion (PROSPECTIVE)

Recruiting
  • UCSF Breast Care Center, San Francisco
Ages 50 and older · Women · Updated Jan 15, 2026 · NCT06445738

Patient Care Outreach, Navigation, Technology and Support 2.0

Recruiting
  • Zuckerberg San Francisco General Hospital, San Francisco
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Jan 13, 2026 · NCT06648278

Prospective Registry of ADC as First- and Second-line Treatment for Breast Cancer

RecruitingObservational studyHealthy volunteers welcome
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Dec 18, 2025 · NCT06774027

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, San Francisco
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • UCSF Breast Care Center, San Francisco
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in San Francisco

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.