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Melanoma clinical trials in Knoxville, TN

5 studies for Melanoma are looking for participants at sites in and around Knoxville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information

RecruitingPhase 2
  • East Tennessee Childrens Hospital, Knoxville
Up to age 25 · All sexes · Updated Sep 24, 2026 · NCT07621614

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • East Tennessee Childrens Hospital, Knoxville
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

RecruitingPhase 2/3
  • University of Tennessee Medical Center, Knoxville
All ages · All sexes · Updated Apr 2, 2026 · NCT06581406

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

RecruitingPhase 3
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

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Other studies in Knoxville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.