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Head and Neck Squamous Cell Carcinoma clinical trials in Rochester, MN

12 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Rochester (within about 30 miles). Open a study to see who can join and how to contact the study team.

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

RecruitingPhase 3
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06992427

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site #0146, Rochester
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #68, Rochester
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • Mayo Rochester, Rochester
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • Mayo Clinic (Rochester), Rochester
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

RecruitingObservational study
  • Mayo Clinic Rochester, Rochester
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06163534

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Oropharynx (OPX) Biomarker Trial

RecruitingObservational study
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT06356272

A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors

RecruitingPhase 1
  • Mayo Clinic Rochester, Rochester
Ages 18 and older · All sexes · Updated Sep 24, 2024 · NCT06259552

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Rochester

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.