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Heart Failure clinical trials in Rochester, MN

22 studies for Heart Failure are looking for participants at sites in and around Rochester (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Mayo Clinic, Rochester, Rochester
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06935370

A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy

RecruitingPhase 1
  • Mayo Clinic, Rochester
Ages 18 to 65 · All sexes · Updated Oct 1, 2026 · NCT07137338

Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

RecruitingObservational studyHealthy volunteers welcome
  • Mayo Clinic, Rochester
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT06517186

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

RecruitingObservational studyHealthy volunteers welcome
  • Mayo Clinic, Rochester
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT05873634

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

RecruitingPhase 2
  • Mayo Clinic, Rochester
Ages 40 to 85 · All sexes · Updated Aug 27, 2026 · NCT06793371

Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume

RecruitingObservational study
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT06195059

Rilonacept in Subjects With Cardiac Sarcoidosis

RecruitingPhase 2
  • Mayo Clinic in Rochester, Rochester
Ages 18 to 80 · All sexes · Updated Aug 20, 2026 · NCT06660732

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • Rochester, Rochester
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Rochester
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

Inspiratory Muscle Training in HFpEF

Recruiting
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06510231

Community-Informed Interventions for Equitable Congestive Heart Failure Management in Primary Care

RecruitingObservational study
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT07730827

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

RecruitingHealthy volunteers welcome
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Jul 17, 2026 · NCT04984473

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

RecruitingObservational study
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06641362

A Study of Paramedic HF Management

RecruitingObservational study
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT06874556

Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II

RecruitingHealthy volunteers welcome
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06271577

AI-Guided Left Bundle Branch Area Pacing

Recruiting
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07206602

His Bundle Pacing in Bradycardia and Heart Failure

RecruitingObservational study
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Dec 24, 2025 · NCT03008291

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

RecruitingObservational study
  • Mayo Clinic-Rochester, Rochester
Ages 18 to 100 · All sexes · Updated Dec 16, 2025 · NCT06039176

Left vs Left Randomized Clinical Trial

Recruiting
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

RecruitingPhase 1
  • Mayo Clinic, Rochester
Ages 18 to 65 · All sexes · Updated Feb 6, 2025 · NCT06228924

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Rochester

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.