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Cancer (all types) clinical trials in Sioux Falls, SD
13 studies for Cancer (all types) are looking for participants at sites in and around Sioux Falls (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)
RecruitingPhase 1/2
- Sanford Children's Hospital ( Site 4015), Sioux Falls
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
RecruitingPhase 2
- Sanford Cancer Center Oncology Clinic and Pharmacy, Sioux Falls
Connect for Cancer Prevention Study (Connect)
RecruitingObservational studyHealthy volunteers welcome
- Sanford Health, Sioux Falls
A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
RecruitingPhase 1/2
- Sanford Children's Hospital ( Site 3015), Sioux Falls
A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
RecruitingPhase 3
- Research Site, Sioux Falls
A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
RecruitingObservational study
- Sanford Sioux Falls, Sioux Falls
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
RecruitingPhase 2
- Sanford Cancer Center Oncology Clinic ( Site 0038), Sioux Falls
Project: Every Child for Younger Patients With Cancer
RecruitingObservational study
- Sanford USD Medical Center - Sioux Falls, Sioux Falls
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
RecruitingPhase 3
- Sanford Cancer Center Oncology Clinic, Sioux Falls
- Avera Cancer Institute, Sioux Falls
- Sanford USD Medical Center - Sioux Falls, Sioux Falls
Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer
RecruitingPhase 3
- Avera Medical Group Gynecologic Oncology Sioux Falls, Sioux Falls
- Texas Oncology, P.A. - Tyler, Sioux Falls
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
RecruitingPhase 2
- Sanford Clinical Research, Sioux Falls
Avera Cancer Sequencing and Analytics Protocol (ASAP)
RecruitingObservational study
- Avera Cancer Institute, Sioux Falls
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
Recruiting
- Sanford Cancer Center Oncology Clinic, Sioux Falls
- Sanford USD Medical Center - Sioux Falls, Sioux Falls
About Cancer (all types)
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More about Cancer (all types) on MedlinePlus
Cancer (all types) trials in other cities
- Houston, TX121 studies
- New York City, NY109 studies
- Boston, MA85 studies
- Los Angeles, CA74 studies
- Nashville, TN65 studies
- Philadelphia, PA59 studies
- Washington, DC58 studies
- Durham, NC58 studies
- Chicago, IL51 studies
- Atlanta, GA49 studies
- Seattle, WA49 studies
- Arlington, VA48 studies
Other studies in Sioux Falls
- Non-Small Cell Lung Cancer19 studies
- Breast Cancer18 studies
- Ovarian Cancer16 studies
- Lung Cancer14 studies
- Endometrial Cancer11 studies
- Metastatic Cancer10 studies
- Colorectal Cancer9 studies
- Head and Neck Squamous Cell Carcinoma9 studies
- Heart Failure7 studies
- Colon Cancer7 studies
- Triple-Negative Breast Cancer7 studies
- Prostate Cancer7 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.