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Colorectal Cancer clinical trials in Portland, OR

28 studies for Colorectal Cancer are looking for participants at sites in and around Portland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Recruiting
  • Oregon Health & Science University (Knight Cancer Institute), Portland
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347

Family Communications After Genetic Testing

RecruitingHealthy volunteers welcome
  • Providence Portland Medical Center, Portland
  • Providence Saint Vincent Medical Center, Portland
  • Providence Willamette Falls Medical Center, Oregon City · 12 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07143487

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Oregon Health & Science University (OHSU), Portland
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

RecruitingPhase 2
  • Oregon Health and Science University, Portland
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Providence Portland Medical Center, Portland
  • Providence Saint Vincent Medical Center, Portland
  • Providence Willamette Falls Medical Center, Oregon City · 12 mi away
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #51, Portland
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

RecruitingPhase 1
  • ALX Center 6, Portland
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Portland
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Kaiser Permanente Interstate Medical Office Central, Portland
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

RecruitingPhase 3
  • Oregon Health And Science University, Portland
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06750094

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

RecruitingPhase 1
  • Research Site, Portland
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

RecruitingPhase 3
  • Oregon Health and Science University, Portland
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT05863195

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

RecruitingPhase 2
  • Research Site, Portland
Ages 18 to 130 · All sexes · Updated Aug 18, 2026 · NCT06792695

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Oregon Health and Science University, Portland
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of MGC026 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Providence Cancer Institute, Portland
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Oregon Health & Science University, Portland
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Investigative Site #121, Portland
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06974110

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

RecruitingPhase 3
  • Providence Cancer Institute Franz Clinic, Portland
  • Providence Portland Medical Center, Portland
  • Providence Oncology and Hematology Care Clinic - Westside, Portland
  • and 5 more
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05253651

Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer

RecruitingPhase 2
  • OHSU Knight Cancer Institute, Portland
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT05705492

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)

RecruitingPhase 2
  • Northwest Cancer Specialists - Compass, Portland
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07011576

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

RecruitingPhase 3Healthy volunteers welcome
  • Providence Portland Medical Center, Portland
  • Providence Saint Vincent Medical Center, Portland
  • Providence Willamette Falls Medical Center, Oregon City · 12 mi away
Ages 18 and older · All sexes · Updated Mar 31, 2026 · NCT07018869

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Kaiser Permanente Northwest, Portland
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Oregon Health Sciences University, Portland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

RecruitingObservational study
  • Providence Portland Medical Center, Portland
  • Providence Saint Vincent Medical Center, Portland
  • Providence Willamette Falls Medical Center, Oregon City · 12 mi away
Ages 18 and older · All sexes · Updated Jan 9, 2026 · NCT06073431

Evaluation of Gixam's Performance in a FIT Negative Population

RecruitingPhase 2
  • The Oregon Clinic Gastroenterology-East, Portland
Ages 45 to 85 · All sexes · Updated Nov 14, 2024 · NCT06612281

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Portland

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.