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Crohn's Disease clinical trials in Boston, MA

19 studies for Crohn's Disease are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

RecruitingPhase 3
  • Massachusetts General Hospital-Crohn's and Colitis Center ( Site 5037), Boston
Ages 16 to 80 · All sexes · Updated Oct 2, 2026 · NCT06430801

Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 75 · All sexes · Updated Oct 2, 2026 · NCT07033208

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Boston Childrens Hospital, Boston
Ages 2 to 17 · All sexes · Updated Sep 25, 2026 · NCT05923073

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
  • Massachusetts General Hospital Cancer Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Tufts Medical Center-Site Number: 8400126, Boston
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184931

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

RecruitingPhase 3
  • Boston Children's Hospital, Boston
Ages 2 to 19 · All sexes · Updated Sep 22, 2026 · NCT04844606

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

RecruitingPhase 3
  • Boston Children's Hospital, Boston
Ages 2 to 17 · All sexes · Updated Aug 24, 2026 · NCT05509777

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

RecruitingObservational study
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07237516

Low Dose IL-2 for the Treatment of Crohn's Disease

RecruitingPhase 1/2
  • Boston Children's Hospital, Boston
  • Brigham and Women's Hospital, Boston
Ages 12 to 80 · All sexes · Updated Aug 3, 2026 · NCT04263831

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Boston Children's Hospital /ID# 262191, Boston
Ages 2 to 17 · All sexes · Updated Jun 24, 2026 · NCT06332534

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

RecruitingPhase 4
  • Boston Children's Hospital, Boston
Ages 6 to 17 · All sexes · Updated May 27, 2026 · NCT05781152

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

RecruitingPhase 3
  • Boston Children's Hospital, Boston
Ages 2 to 17 · All sexes · Updated May 5, 2026 · NCT04779320

A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

RecruitingPhase 2
  • Investigational Site Number: 8400022, Boston
Ages 18 to 75 · All sexes · Updated Mar 27, 2026 · NCT06958536

Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.

RecruitingObservational study
  • Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown · 1 mi away
Ages 18 to 99 · All sexes · Updated Mar 12, 2026 · NCT06252493

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 14 and older · All sexes · Updated Jan 30, 2026 · NCT05332639

A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 75 · All sexes · Updated Dec 16, 2025 · NCT07219537

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

RecruitingObservational studyHealthy volunteers welcome
  • Boston Children's Hospital, Boston
Ages 13 to 20 · All sexes · Updated Oct 30, 2025 · NCT04508088

High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy

RecruitingObservational study
  • Boston Children's Hospital, Boston
Ages 5 to 25 · All sexes · Updated Mar 3, 2025 · NCT04331639

Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 14 and older · All sexes · Updated Dec 20, 2024 · NCT06655415

About Crohn's Disease

Crohn's Disease can cause inflammation in any area from the mouth to the anus. Read about medicines, surgery or dietary management to treat symptoms.

More about Crohn's Disease on MedlinePlus

Crohn's Disease trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.