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Oral Cancer clinical trials in Chicago, IL

8 studies for Oral Cancer are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • University of Chicago Comprehensive Cancer Center, Chicago
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

RecruitingPhase 2
  • Rush MD Anderson Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07195734

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Illinois, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

RecruitingPhase 1
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT05172245

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • John H Stroger Jr Hospital of Cook County, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Northwestern University, Chicago
  • Rush MD Anderson Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

RecruitingPhase 3
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07441681

About Oral Cancer

Oral cancer can form in the mouth or throat but usually begins in the tongue and floor of the mouth. Read about the common oral cancer symptoms.

More about Oral Cancer on MedlinePlus

Oral Cancer trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.