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Crohn's Disease clinical trials in Philadelphia, PA

13 studies for Crohn's Disease are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

RecruitingPhase 3
  • Thomas Jefferson University Hospital ( Site 5133), Philadelphia
Ages 16 to 80 · All sexes · Updated Oct 2, 2026 · NCT06430801

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

RecruitingPhase 2
  • University of Pennsylvania - Perelman Center for Advanced Medicine /ID# 265904, Philadelphia
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT06548542

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Children's Hospital of Philadelphia, Philadelphia
Ages 2 to 17 · All sexes · Updated Sep 25, 2026 · NCT05923073

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2/3
  • University of Pennsylvania, Philadelphia
  • Jefferson Digestive Health Institute, Philadelphia
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07196722

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • Thomas Jefferson University - Medicine/GI and Hepatology, Philadelphia
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937099

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • University of Pennsylvania School of Medicine-Site Number: 8400072, Philadelphia
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184931

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • University of Pennsylvania School of Medicine-Site Number: 8400072, Philadelphia
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184944

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

RecruitingPhase 3
  • Children's Hospital of Philadelphia (CHOP), Philadelphia
Ages 2 to 19 · All sexes · Updated Sep 22, 2026 · NCT04844606

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

RecruitingPhase 3
  • Children's Hospital of Philadelphia, Philadelphia
Ages 2 to 17 · All sexes · Updated Aug 24, 2026 · NCT05509777

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Children's Hospital of Philadelphia - Main /ID# 262197, Philadelphia
Ages 2 to 17 · All sexes · Updated Jun 24, 2026 · NCT06332534

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

RecruitingPhase 4
  • Children's Hospital of Philadelphia, Philadelphia
Ages 6 to 17 · All sexes · Updated May 27, 2026 · NCT05781152

Precise Infliximab Exposure and Pharmacodynamic Control

RecruitingPhase 2/3
  • Nemours Children's Health System-Wilmington, Wilmington · 25 mi away
Ages 6 to 22 · All sexes · Updated May 5, 2026 · NCT05660746

Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial

Recruiting
  • Children's Hospital of Philadelphia, Philadelphia
Ages 8 to 21 · All sexes · Updated Jun 12, 2025 · NCT06216899

About Crohn's Disease

Crohn's Disease can cause inflammation in any area from the mouth to the anus. Read about medicines, surgery or dietary management to treat symptoms.

More about Crohn's Disease on MedlinePlus

Crohn's Disease trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.