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Epilepsy clinical trials recruiting in the U.S.
98 studies for Epilepsy are recruiting participants at sites across the United States.
Epilepsy is a brain disorder that causes people to have seizures. The seizures may be mild or severe. Learn about causes, diagnosis, and treatment.
Cities with the most studies
- Boston, MA19 studies
- Houston, TX16 studies
- New York City, NY13 studies
- Washington, DC12 studies
- Philadelphia, PA11 studies
- Cleveland, OH9 studies
- Phoenix, AZ9 studies
- Durham, NC8 studies
- Rochester, MN8 studies
- Birmingham, AL7 studies
- Mountain View, CA7 studies
- St. Louis, MO7 studies
- Miami, FL7 studies
- Nashville, TN6 studies
- Los Angeles, CA6 studies
- Jacksonville, FL6 studies
- Aurora, CO5 studies
- Chicago, IL5 studies
- Cincinnati, OH5 studies
- Charlotte, NC5 studies
- Dallas, TX4 studies
- Minneapolis, MN4 studies
- Pittsburgh, PA4 studies
- Baltimore, MD4 studies
- Orange, CA4 studies
- Boise, ID4 studies
- Ann Arbor, MI4 studies
- Columbus, OH4 studies
- Clifton, NJ4 studies
- Detroit, MI4 studies
- Akron, OH3 studies
- San Diego, CA3 studies
- New Haven, CT3 studies
- Kansas City, KS3 studies
- Sacramento, CA3 studies
- Salt Lake City, UT3 studies
- Tampa, FL3 studies
- San Francisco, CA3 studies
- Tucson, AZ3 studies
- Atlanta, GA3 studies
By state
- Alabama9 studies
- Arizona10 studies
- Arkansas4 studies
- California20 studies
- Colorado6 studies
- Connecticut3 studies
- Florida13 studies
- Georgia4 studies
- Idaho4 studies
- Illinois7 studies
- Kansas3 studies
- Maryland15 studies
- Massachusetts22 studies
- Michigan9 studies
- Minnesota10 studies
- Missouri8 studies
- New Hampshire6 studies
- New Jersey4 studies
- New York17 studies
- North Carolina11 studies
- Ohio17 studies
- Oregon3 studies
- Pennsylvania13 studies
- Tennessee7 studies
- Texas21 studies
- Utah3 studies
- Virginia3 studies
- Washington3 studies
- Wisconsin3 studies
Recently updated studies
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06038929Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 120 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02107989Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
RecruitingPhase 2
1 Day โ 6 Months ยท All sexes ยท Updated Oct 2, 2026 ยท NCT05104983Investigating Epilepsy: Screening and Evaluation
RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT03478852Surgery as a Treatment for Medically Intractable Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT01273129Tumor Related Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02639325Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07563881Evaluation and Treatment of Neurosurgical Disorders
RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Sep 29, 2026 ยท NCT00060541Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT02531880Modulating Movement Intention Via Cortical Stimulation
RecruitingHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT03233399Prospective Natural History Study of POLG Disease
RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07775872Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
RecruitingObservational study
Ages 18 to 75 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07110454A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06388707Diagnosing Epilepsy To EffeCT Change
Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07110337SeizEAR Safety Study
RecruitingHealthy volunteers welcome
Ages 18 to 70 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07088835Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 2, 2026 ยท NCT07594119Physiological Brain Atlas Development
RecruitingObservational study
Ages 6 to 90 ยท All sexes ยท Updated Aug 26, 2026 ยท NCT00575081AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
RecruitingPhase 1/2
Ages 18 to 75 ยท All sexes ยท Updated Aug 24, 2026 ยท NCT06063850Brain Development Research Program
RecruitingObservational study
All ages ยท All sexes ยท Updated Aug 17, 2026 ยท NCT00305305Subcortical Arousal in Perceptual Awareness
Recruiting
Ages 13 and older ยท All sexes ยท Updated Aug 10, 2026 ยท NCT06934356A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
RecruitingPhase 3
Ages 12 and older ยท All sexes ยท Updated Aug 10, 2026 ยท NCT05667142Implementation and Cost Evaluation of Project UPLIFT
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 7, 2026 ยท NCT06865820Sleep Architecture & Cognition in Focal Epilepsy
Recruiting
Ages 18 to 40 ยท All sexes ยท Updated Aug 7, 2026 ยท NCT05794295Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
RecruitingObservational study
Up to age 26 ยท All sexes ยท Updated Aug 6, 2026 ยท NCT05374824Outcomes After Planned Discontinuation of AntiSeizure Medication
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07750496From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.