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Epilepsy clinical trials in Cleveland, OH

9 studies for Epilepsy are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

RecruitingPhase 3
  • Cleveland Clinic, Cleveland
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT07563881

Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

RecruitingObservational study
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 to 75 · All sexes · Updated Sep 15, 2026 · NCT07110454

AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

RecruitingPhase 1/2
  • Cleveland Clinic, Cleveland
Ages 18 to 75 · All sexes · Updated Aug 24, 2026 · NCT06063850

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

RecruitingPhase 3
  • Cleveland Clinic Foundation, Cleveland
Ages 12 and older · All sexes · Updated Aug 10, 2026 · NCT05667142

Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery

Recruiting
  • Cleveland Clinic, Cleveland
Ages 18 to 60 · All sexes · Updated Jun 18, 2026 · NCT05992402

Healthy Aging in People With Epilepsy Program

RecruitingHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 55 to 90 · All sexes · Updated Jun 12, 2026 · NCT06052605

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

RecruitingPhase 3
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT05716100

Bridging the Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes

RecruitingHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Apr 3, 2026 · NCT07509190

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

RecruitingPhase 2
  • Cleveland Clinic Foundation, Cleveland
Ages 18 to 70 · All sexes · Updated Jan 23, 2026 · NCT07219407

About Epilepsy

Epilepsy is a brain disorder that causes people to have seizures. The seizures may be mild or severe. Learn about causes, diagnosis, and treatment.

More about Epilepsy on MedlinePlus

Epilepsy trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.