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Amygdala Memory Enhancement

Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

Who can join

Ages 18 to 75 · All sexes

Inclusion Criteria:

* Must be able to understand and speak English.
* Able to provide informed consent.
* Diagnosed with epilepsy.
* Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization.
* Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices.

Exclusion Criteria:

* Unable to understand and speak English.
* Unable to provide informed consent.
* Not diagnosed with epilepsy.

About the study

The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

What is being tested

• Intracranial Stimulation (device)

Sponsor: Washington University School of Medicine · Participants: 90 · Started: Nov 1, 2021

Contact the study team

• Joan Atencio · Phone: 314-362-3114
• Sophie Church · Phone: 917-699-9097

Official record on ClinicalTrials.gov — NCT05065450

Locations in the U.S.

Conditions

• Brain Diseases
• Epilepsy
• Memory
• Traumatic Brain Injury
• Mild Cognitive Impairment
• Post-Traumatic Stress Disorder

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.