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Colorectal Cancer clinical trials in Sioux Falls, SD

9 studies for Colorectal Cancer are looking for participants at sites in and around Sioux Falls (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Avera Medical Group, Sioux Falls
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

RecruitingPhase 2
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Avera Cancer Institute, Sioux Falls
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

RecruitingPhase 3
  • Avera Cancer Institute, Sioux Falls
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05253651

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

RecruitingObservational study
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 60 and older · All sexes · Updated Jan 8, 2026 · NCT03998202

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Sioux Falls

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.