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Schizophrenia clinical trials recruiting in the U.S.

106 studies for Schizophrenia are recruiting participants at sites across the United States.

Schizophrenia is a serious brain illness that can include hearing voices that aren't there and thinking others are trying to hurt them.

Cities with the most studies

By state

Recently updated studies

Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1

RecruitingHealthy volunteers welcome
Ages 18 to 59 · All sexes · Updated Oct 2, 2026 · NCT07853807

Safety and Tolerability of Open-Labeled Iloperidone in Adolescents

RecruitingPhase 4
Ages 12 to 17 · All sexes · Updated Oct 1, 2026 · NCT05648591

iTBS to Enhance Social Cognition in People With Psychosis

Recruiting
Ages 18 to 39 · All sexes · Updated Oct 1, 2026 · NCT06118268

Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls

RecruitingHealthy volunteers welcome
Ages 18 to 50 · All sexes · Updated Oct 1, 2026 · NCT07680114

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07101094

Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy

Recruiting
Ages 18 to 65 · All sexes · Updated Sep 30, 2026 · NCT06835556

Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 28, 2026 · NCT07686263

NBI-1117568-SCZ3030: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07105098

NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07114874

Efficacy of NBI-1117568 in Preventing Relapse in Adults With Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07227818

Study to Evaluate the Safety and Efficacy of Ublituximab in Participants With Schizophrenia

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Sep 23, 2026 · NCT07680946

A Study of Brenipatide in Adult Participants With Schizophrenia

RecruitingPhase 2
Ages 18 to 55 · All sexes · Updated Sep 22, 2026 · NCT07410507

State Representation in Early Psychosis 2

RecruitingObservational studyHealthy volunteers welcome
Ages 15 to 45 · All sexes · Updated Sep 22, 2026 · NCT07834203

A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia

RecruitingPhase 1
Ages 18 to 55 · All sexes · Updated Sep 17, 2026 · NCT07734493

Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

Recruiting
Ages 22 to 65 · All sexes · Updated Sep 16, 2026 · NCT05276050

52-week Open Label Safety-Tolerability Study

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 9, 2026 · NCT07369154

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

RecruitingPhase 3
Ages 13 to 17 · All sexes · Updated Sep 4, 2026 · NCT07288567

A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT

RecruitingPhase 1
Ages 18 to 55 · All sexes · Updated Sep 2, 2026 · NCT07061288

Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans

RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Sep 2, 2026 · NCT06058702

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.