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Non-Small Cell Lung Cancer clinical trials in Seattle, WA

53 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Seattle (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

RecruitingPhase 3
  • Swedish Cancer Institute ( Site 0143), Seattle
  • St. Joseph Medical Center Hematology and Oncology - Silverdale ( Site 0192), Silverdale · 17 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06623422

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Washington, Fred Hutchinson Cancer Center, Seattle
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

RecruitingPhase 3
  • Swedish Medical Center-First Hill, Seattle
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06498635

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

RecruitingPhase 3
  • University of Washington - Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06765109

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

RecruitingPhase 2
  • Swedish Cancer Institute, Seattle
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05498428

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Swedish Medical Center, Seattle
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06890598

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

RecruitingPhase 2
  • Fred Hutchinson Cancer Center, Seattle
  • University of Washington Medical Center - Montlake, Seattle
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT03191149

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Swedish Medical Center, Seattle
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06618287

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

RecruitingPhase 2
  • Research Site, Seattle
Ages 18 to 95 · All sexes · Updated Sep 23, 2026 · NCT05061550

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

RecruitingPhase 1/2
  • University of Washington Fred Hutchinson Cancer Center, Seattle
Ages 18 to 99 · All sexes · Updated Sep 22, 2026 · NCT06814496

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • University of Washington Fred Hutchinson, Seattle
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

RecruitingPhase 3
  • Clinical Study Site, Seattle
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06767514

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Research Center, Seattle
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

RecruitingPhase 2
  • University of Washington (Data Collection Only), Seattle
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04410796

A Study of KK2269 in Adult Participants With Solid Tumors

RecruitingPhase 1
  • University of Washington, Seattle
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06266299

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Swedish Medical Center, Seattle
  • VA Puget Sound Health Care System, Seattle
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06343402

SX-682 and Atezolizumab for the Treatment of Advanced or Metastatic, Recurrent Non-small Cell Lung Cancer

RecruitingPhase 2
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT07322341

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

RecruitingPhase 2
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT06518057

SMP-3124LP in Adults With Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Washington, Seattle
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819

PET/CT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung Cancer

Recruiting
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT04151940

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06706076

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07444814

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

RecruitingPhase 1/2
  • Swedish Cancer Institute, Seattle
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT05579366

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • University Of Washington, Seattle
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

RecruitingPhase 1
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05098210

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Swedish Cancer Institute, Seattle
  • Swedish Medical Center, Seattle
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Research Center, Seattle
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT06162221

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

RecruitingPhase 2
  • Seattle Cancer Care Alliance, Seattle
Ages 18 to 70 · All sexes · Updated Jun 26, 2026 · NCT04614103

Exercise Training for the Improvement of Immune Activity and Treatment Outcomes During Immunotherapy for Non-small Cell Lung Cancer, BOOST Trial

Recruiting
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06983899

SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer

RecruitingPhase 2
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT05570825

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06051695

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Fred Hutchinson Cancer Center, Seattle
  • Swedish Medical Center-First Hill, Seattle
  • FHCC at Northwest Hospital, Seattle
  • and 1 more
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Virginia Mason Medical Center, Seattle
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Swedish Medical Center-First Hill, Seattle
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06116682

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Swedish Medical Center-First Hill, Seattle
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • Virginia Mason Medical Center, Seattle
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Swedish Cancer Institute, Seattle
  • Swedish Medical Center, Seattle
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT04606446

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Kaiser Permanente Washington, Seattle
  • Swedish Medical Center-First Hill, Seattle
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Seattle
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Fred Hutch Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06682793

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

RecruitingPhase 1
  • Swedish Health Sciences, Seattle
  • Research Site, Seattle
Ages 18 and older · All sexes · Updated Apr 23, 2025 · NCT06046495

A Study of IBI363 in Subjects with Advanced Solid Malignancies

RecruitingPhase 2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Dec 19, 2024 · NCT06281678

Non-Small Cell Lung Cancer trials in other cities

Other studies in Seattle

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.