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Colorectal Cancer clinical trials in Seattle, WA

34 studies for Colorectal Cancer are looking for participants at sites in and around Seattle (within about 30 miles). Open a study to see who can join and how to contact the study team.

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Research Center, Seattle
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06324357

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer

RecruitingPhase 2
  • Virginia Mason Medical Center, Seattle
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07659795

A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

RecruitingPhase 3
  • University Of Washington-Fred Hutchinson Cancer Center - Seattle /ID# 281451, Seattle
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07525206

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 2
  • University Of Washington-Fred Hutchinson Cancer Center - Seattle /ID# 271298, Seattle
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06820463

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Swedish Cancer Institute, Seattle
  • Fred Hutchinson Cancer Center, Seattle
  • Swedish Medical Center, Seattle
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

RecruitingPhase 3
  • Swedish Cancer Institute, Seattle
  • Fred Hutchinson Cancer Research Center, Seattle
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06662786

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

RecruitingPhase 3
  • Fred Hutchinson Cancer Research Center, Seattle
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06750094

A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

RecruitingPhase 1
  • Swedish Cancer Institute, Seattle
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06663319

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06445062

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Research Center, Seattle
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Washington, Fred Hutchinson Cancer Center, Seattle
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06625775

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Swedish Medical Center-Ballard Campus, Seattle
  • Swedish Medical Center-Cherry Hill, Seattle
  • Swedish Medical Center-First Hill, Seattle
  • and 1 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

Family Communications After Genetic Testing

RecruitingHealthy volunteers welcome
  • Swedish Medical Center-Ballard Campus, Seattle
  • Swedish Medical Center-Cherry Hill, Seattle
  • Swedish Medical Center-First Hill, Seattle
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07143487

A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer

RecruitingPhase 2
  • Swedish Cancer Institute, Seattle
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06992258

Improving Uptake of Surveillance in Colorectal Cancer Survivors Through Navigation and Web Education

Recruiting
  • Benaroya Research Institute at Virginia Mason, Seattle
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06995924

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

RecruitingObservational study
  • University of Washington, Seattle
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT05410977

A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT07066657

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • University Of Washington, Seattle
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immunochemical Test Results, PROACT Trial

RecruitingHealthy volunteers welcome
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 45 to 75 · All sexes · Updated Jun 22, 2026 · NCT06822530

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06051695

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Virginia Mason Medical Center, Seattle
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • Virginia Mason Medical Center, Seattle
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

RecruitingPhase 3Healthy volunteers welcome
  • Swedish Medical Center-Ballard Campus, Seattle
  • Swedish Medical Center-Cherry Hill, Seattle
  • Swedish Medical Center-First Hill, Seattle
  • and 1 more
Ages 18 and older · All sexes · Updated Mar 31, 2026 · NCT07018869

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Kaiser Permanente Washington, Seattle
  • Swedish Medical Center-First Hill, Seattle
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Fred Hutch Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06682793

ColoCare Study - Colorectal Cancer Cohort

RecruitingObservational study
  • FHCRC, Seattle
Ages 18 to 89 · All sexes · Updated Jun 13, 2025 · NCT02328677

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

RecruitingObservational study
  • University of Washington / Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated May 6, 2025 · NCT05234177

A Study of IBI363 in Subjects with Advanced Solid Malignancies

RecruitingPhase 2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Dec 19, 2024 · NCT06281678

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Seattle

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.