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Esophageal Cancer clinical trials in Philadelphia, PA

13 studies for Esophageal Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

RecruitingHealthy volunteers welcome
  • Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
  • Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07283939

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Philadelphia
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

RecruitingPhase 2
  • University of Pennsylvania (Data Collection Only), Philadelphia
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • University of Pennsylvania, Philadelphia
  • Fox Chase Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Prehabilitation in High-risk Oncologic Surgery

Recruiting
  • Fox Chase Cancer Center - Philadelphia, Philadelphia
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07638410

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

RecruitingPhase 3
  • University of Pennsylvania, Perelman School of Medicine, Philadelphia
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT00288119

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial

Recruiting
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Feb 10, 2026 · NCT05775939

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Philadelphia
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Esophageal Cancer

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

More about Esophageal Cancer on MedlinePlus

Esophageal Cancer trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.