Home › Head and Neck Cancer
Head and Neck Cancer clinical trials recruiting in the U.S.
146 studies for Head and Neck Cancer are recruiting participants at sites across the United States.
Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.
Cities with the most studies
- Houston, TX30 studies
- Boston, MA22 studies
- New York City, NY21 studies
- Nashville, TN21 studies
- St. Louis, MO15 studies
- Dallas, TX12 studies
- Pittsburgh, PA11 studies
- Durham, NC10 studies
- San Antonio, TX10 studies
- Los Angeles, CA10 studies
- Chicago, IL10 studies
- Washington, DC10 studies
- Baltimore, MD10 studies
- Miami, FL10 studies
- Edison, NJ9 studies
- Philadelphia, PA9 studies
- Tampa, FL9 studies
- Cleveland, OH9 studies
- San Francisco, CA9 studies
- Rochester, MN8 studies
- Columbus, OH8 studies
- Portland, OR8 studies
- New Haven, CT8 studies
- Charleston, SC8 studies
- San Diego, CA7 studies
- Baldwin Park, CA7 studies
- New Rochelle, NY6 studies
- Queens, NY6 studies
- Staten Island, NY6 studies
- Arlington, VA6 studies
- Aurora, CO6 studies
- Mountain View, CA6 studies
- Orlando, FL6 studies
- Birmingham, AL5 studies
- Sacramento, CA5 studies
- Newark, NJ5 studies
- Memphis, TN5 studies
- Atlanta, GA5 studies
- Cedar Rapids, IA5 studies
- Milwaukee, WI5 studies
By state
- Alabama5 studies
- Arizona4 studies
- Arkansas3 studies
- California31 studies
- Colorado9 studies
- Connecticut10 studies
- Delaware3 studies
- District of Columbia5 studies
- Florida24 studies
- Georgia7 studies
- Illinois11 studies
- Iowa5 studies
- Kansas7 studies
- Kentucky5 studies
- Louisiana3 studies
- Maryland15 studies
- Massachusetts24 studies
- Michigan10 studies
- Minnesota10 studies
- Missouri16 studies
- Nebraska4 studies
- New Jersey13 studies
- New Mexico3 studies
- New York29 studies
- North Carolina14 studies
- Ohio19 studies
- Oklahoma6 studies
- Oregon8 studies
- Pennsylvania20 studies
- Rhode Island4 studies
- South Carolina10 studies
- Tennessee23 studies
- Texas42 studies
- Utah7 studies
- Virginia12 studies
- Washington5 studies
- Wisconsin8 studies
Recently updated studies
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers
RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Oct 2, 2026 · NCT06479811Biospecimen Procurement for Head and Neck Disorders
RecruitingObservational study
Ages 3 to 120 · All sexes · Updated Oct 2, 2026 · NCT03429036A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06997068A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091Online Perioperative Education Program on Patient Satisfaction and Clinical Outcomes for Head and Neck Surgery
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07848841A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07814248NIDCD Otolaryngology Clinical Protocol Biospecimen Bank
RecruitingObservational study
Ages 3 to 99 · All sexes · Updated Sep 28, 2026 · NCT06303180DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000Pilot Study of Management of Facial Paralysis in the Oncologic Patient: Nerve Transfer Techniques to Improve Facial Function and Quality of Life
Recruiting
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667427Intratumoral N17350 in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176Continuous Monitoring of Microvascular Anastomoses: An Observational Trial
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07823283Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck
Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07644585Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery
Recruiting
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06607406A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07020117Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06096038Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06633224Effects of Infusion Timing on Treatment Response in Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07630168Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06722508First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.