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Ovarian Cancer clinical trials in Durham, NC

27 studies for Ovarian Cancer are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Durham VA Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

RecruitingPhase 2/3
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
  • University of North Carolina-Hillsborough Campus, Hillsborough · 13 mi away
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07001748

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Duke University Medical Center, Durham
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

A Study of PHST001 in Advanced Solid Tumors

RecruitingPhase 1
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06840886

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Duke University, Durham
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

RecruitingPhase 2
  • Site 0259 - Duke Cancer Center, Durham
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT05128825

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Durham
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

RecruitingPhase 3
  • Duke Cancer Center ( Site 0012), Durham
Ages 18 and older · Women · Updated Sep 17, 2026 · NCT07318558

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • UNC- Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Recruiting
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 35 to 50 · Women · Updated Aug 7, 2026 · NCT04251052

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

RecruitingPhase 3
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

RecruitingPhase 3
  • UNC Hospital, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Jul 2, 2026 · NCT06819007

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated May 19, 2026 · NCT06305299

Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

RecruitingPhase 3
  • Duke Cancer Center, Durham
Ages 18 and older · Women · Updated Apr 16, 2026 · NCT05659381

REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors

Recruiting
  • Duke Cancer Center, Durham
Ages 18 and older · Women · Updated Apr 13, 2026 · NCT06710548

A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer

RecruitingPhase 1
  • Site 0259, Durham
Ages 18 and older · Women · Updated Apr 7, 2026 · NCT04516447

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Recruiting
  • Duke University Hospital, Durham
Ages 25 to 50 · Women · Updated Apr 6, 2026 · NCT04294927

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

RecruitingPhase 1/2
  • Duke Cancer Center/ DUMC, Durham
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT05735080

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

RecruitingPhase 2
  • Duke Cancer Center, Durham
Ages 18 and older · Women · Updated Dec 23, 2025 · NCT06690775

Multimedia Aid for Genetic Testing in Gynecologic Oncology

Recruiting
  • Univeristy of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Nov 12, 2025 · NCT07084168

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Ovarian Cancer

Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. The ovaries are a pair of female reproductive glands that make eggs and female hormones.

More about Ovarian Cancer on MedlinePlus

Ovarian Cancer trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.