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Healthy volunteer studies in Columbia, MO

41 studies at sites in and around Columbia accept healthy volunteers — people without the condition being studied. Many studies pay participants for their time and travel; the amount is set by each study, so ask the study team.

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 45 · All sexes · Updated Sep 25, 2026 · NCT06433115

Insomnia and Insulin Resistance

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 50 · All sexes · Updated Sep 24, 2026 · NCT07333586

Sleep as a Mechanism of Change in Alcohol Use

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 49 · All sexes · Updated Sep 14, 2026 · NCT06286774

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 70 · Women · Updated Sep 10, 2026 · NCT06417177

Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 70 · Women · Updated Sep 10, 2026 · NCT07674680

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

RecruitingPhase 3Healthy volunteers welcome
  • University of Missouri Pediatrics Clinic-South Providence, Columbia
  • University of Missouri, Columbia
42 Days – 211 Days · All sexes · Updated Sep 8, 2026 · NCT07629440

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

RecruitingPhase 4Healthy volunteers welcome
  • University of Missouri Health System, Columbia
Ages 75 and older · All sexes · Updated Sep 1, 2026 · NCT04262206

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 70 · All sexes · Updated Aug 6, 2026 · NCT06335771

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 70 · All sexes · Updated Aug 6, 2026 · NCT06571474

Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06286761

Impact of Sleep Restriction on Blood Pressure Reactivity

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 45 · All sexes · Updated Jul 28, 2026 · NCT07489417

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 45 · All sexes · Updated Jul 28, 2026 · NCT05219799

Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT04632628

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

RecruitingPhase 3Healthy volunteers welcome
  • GSK Investigational Site, Jefferson City · 27 mi away
12 Months – 15 Months · All sexes · Updated May 29, 2026 · NCT06740630

Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 59 · All sexes · Updated May 11, 2026 · NCT06571500

High Protein Diet and Atherosclerosis

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 45 to 75 · All sexes · Updated May 11, 2026 · NCT05235464

Growth Hormone Resistance of Beta-cells A

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 45 · Women · Updated May 11, 2026 · NCT06571487

Animal and Plant Proteins and Glucose Metabolism

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 21 to 70 · All sexes · Updated May 8, 2026 · NCT03994367

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 100 · All sexes · Updated May 7, 2026 · NCT07083557

Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 100 · Women · Updated May 5, 2026 · NCT05846438

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

RecruitingObservational studyHealthy volunteers welcome
  • Ellis Fischel Cancer Center, University of Missouri, Columbia
Ages 18 and older · All sexes · Updated May 1, 2026 · NCT02838836

Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 60 · All sexes · Updated Mar 11, 2026 · NCT07220265

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

RecruitingHealthy volunteers welcome
  • NextGen Precision Health Building, Clinical and Translational Science Unit, Columbia
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06689618

Lipoprotein Kinetics in T1D

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 45 · All sexes · Updated Feb 10, 2026 · NCT05179954

Empagliflozin Reversal of Arterial StiffnEss in Aging

RecruitingPhase 2/3Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 60 to 80 · All sexes · Updated Feb 6, 2026 · NCT06506422

Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri - Columbia, Columbia
Up to age 99 · All sexes · Updated Jan 9, 2026 · NCT07329257

Early Neurovascular Adaptations in Aging Women

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 70 · Women · Updated Nov 26, 2025 · NCT06520982

Brain Blood Flow and Lactate in Non-obese and Obese Subjects

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 45 · All sexes · Updated Nov 26, 2025 · NCT06791837

Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

RecruitingPhase 2Healthy volunteers welcome
  • Harry S. Truman Memorial, Columbia, MO, Columbia
Ages 30 to 60 · All sexes · Updated Nov 14, 2025 · NCT06745063

An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction

RecruitingPhase 2Healthy volunteers welcome
  • University of Missouri - Columbia, Columbia
Ages 18 to 65 · All sexes · Updated Oct 28, 2025 · NCT03713424

CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)

RecruitingPhase 4Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 and older · All sexes · Updated Oct 15, 2025 · NCT05846399

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

RecruitingObservational studyHealthy volunteers welcome
  • Harry S Truman Veterans Memorial Hospital, Columbia
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03551951

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 70 · Women · Updated Sep 15, 2025 · NCT06787066

Remote Sensing for ADRD-Specific Activities Identification in Older Adults

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 50 and older · All sexes · Updated Aug 13, 2025 · NCT07120347

Dietary Fiber Effects on the Microbiome and Satiety

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 20 to 55 · All sexes · Updated Jun 22, 2025 · NCT04611217

Implementation Supports for Improving Identification and Delivery of School-based Mental Health Supports for Middle Schools Students

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 10 to 99 · All sexes · Updated Jun 19, 2025 · NCT06047041

Outcomes Following Combined Adductoplasty™ and Lapiplasty® (MTA3D)

RecruitingHealthy volunteers welcome
  • JCMG - Jefferson City Medical Group, Jefferson City · 27 mi away
Ages 14 to 65 · All sexes · Updated May 25, 2025 · NCT05587569

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Myasthenia Gravis

RecruitingHealthy volunteers welcome
  • NextGen Precision Health Building, Clinical and Translational Science Unit, Columbia
Ages 18 and older · All sexes · Updated Apr 10, 2025 · NCT06064695

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

RecruitingHealthy volunteers welcome
  • Office of Dental Health, Department of Health and Senior Services, Jefferson City · 27 mi away
Ages 60 to 100 · All sexes · Updated Mar 26, 2025 · NCT06890676

NeuroControl of Nicotine Dependence

RecruitingHealthy volunteers welcome
  • Health Neuroscience Center, Columbia
Ages 18 to 60 · All sexes · Updated Oct 1, 2024 · NCT06347055

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.