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Acute Myeloid Leukemia clinical trials in Chicago, IL

27 studies for Acute Myeloid Leukemia are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 to 59 · All sexes · Updated Sep 28, 2026 · NCT05554393

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

RecruitingPhase 1
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06484062

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • University of Chicago Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06852222

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05564390

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06672146

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06317649

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 to 59 · All sexes · Updated Sep 22, 2026 · NCT05554406

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

RecruitingPhase 3
  • Lurie Children's Hospital-Chicago, Chicago
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
6 Months – 21 Years · All sexes · Updated Sep 17, 2026 · NCT04293562

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

RecruitingPhase 1/2
  • The University of Chicago Medical Center, Chicago
30 Days · All sexes · Updated Sep 16, 2026 · NCT04065399

A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML)

RecruitingPhase 1/2
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06969430

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

RecruitingPhase 3
  • Lurie Children's Hospital-Chicago, Chicago
Ages 1 to 25 · All sexes · Updated Sep 4, 2026 · NCT07022678

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mount Sinai Hospital Medical Center, Chicago
  • John H Stroger Jr Hospital of Cook County, Chicago
  • University of Illinois, Chicago
  • and 1 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • US-Chigago IL-UHCHICAGO, Chicago
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07223814

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

RecruitingPhase 1/2
  • Lurie Children's Hospital-Chicago, Chicago
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Up to age 22 · All sexes · Updated Aug 25, 2026 · NCT04726241

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
  • Comer Children's Hospital, Chicago
29 Days – 21 Years · All sexes · Updated Aug 24, 2026 · NCT05183035

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

RecruitingPhase 1
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT06001788

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

RecruitingObservational study
  • Northwestern Memorial Hospital, Chicago
  • Rush University Medical Center, Chicago
  • University of Illinois at Chicago, Chicago
  • and 2 more
All ages · All sexes · Updated Jul 6, 2026 · NCT01351545

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

RecruitingPhase 1
  • University of Chicago, Chicago
Ages 13 and older · All sexes · Updated May 5, 2026 · NCT04771572

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

RecruitingPhase 1/2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT05732103

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

RecruitingPhase 1/2
  • Northwestern, Chicago
Ages 12 and older · All sexes · Updated Mar 24, 2026 · NCT04988555

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

RecruitingPhase 1
  • Northwestern Medicine, Chicago
Ages 12 and older · All sexes · Updated Mar 16, 2026 · NCT06994676

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

RecruitingPhase 1
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT05735184

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

RecruitingPhase 1
  • Northwestern Medicine - Northwestern Memorial Hospital Galter Pavilion, Chicago
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT06501196

About Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is a cancer of the white blood cells. AML usually gets worse quickly if it is not treated. Read more.

More about Acute Myeloid Leukemia on MedlinePlus

Acute Myeloid Leukemia trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.