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ALS and Motor Neuron Disease clinical trials recruiting in the U.S.
23 studies for ALS and Motor Neuron Disease are recruiting participants at sites across the United States.
Cities with the most studies
- Washington, DC7 studies
- Boston, MA4 studies
- Jacksonville, FL4 studies
- Philadelphia, PA3 studies
- Houston, TX3 studies
- New York City, NY3 studies
By state
- California5 studies
- Florida7 studies
- Maryland7 studies
- Massachusetts6 studies
- Minnesota3 studies
- Missouri3 studies
- New York3 studies
- Pennsylvania4 studies
- Texas6 studies
Recently updated studies
Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT07204977Developing New Ways to Detect Respiratory Impairment Early in ALS
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07844590Study of Inherited Neurological Disorders
RecruitingObservational study
Ages 2 to 120 · All sexes · Updated Sep 28, 2026 · NCT00004568Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers
RecruitingHealthy volunteers welcome
Ages 2 to 110 · All sexes · Updated Sep 28, 2026 · NCT01900132Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Sep 17, 2026 · NCT03225144Biofluid Research on Age-Related or Inherited Neurodegeneration
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · Men · Updated Aug 13, 2026 · NCT04944940Healing ALS Registry Observational Study (HAROS)
RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Jun 24, 2026 · NCT07233148Clinical Procedures to Support Research in ALS
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03489278A Study of Ranolazine in ALS
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06527222Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.
Recruiting
Ages 18 and older · All sexes · Updated May 27, 2026 · NCT07187388INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study
Recruiting
Ages 22 and older · All sexes · Updated May 11, 2026 · NCT07543367Non-invasive BCI-controlled Assistive Devices
RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated May 1, 2026 · NCT05183152The National Amyotrophic Lateral Sclerosis Registry
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT01772602AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth
RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT07491484Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
RecruitingObservational study
1 Month – 30 Years · All sexes · Updated Mar 18, 2026 · NCT05354622Spastic Paraplegia - Centers of Excellence Research Network
RecruitingObservational study
All ages · All sexes · Updated Mar 18, 2026 · NCT06553976Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
Recruiting
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT07478172Imaging Biomarkers in ALS
RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 75 · All sexes · Updated Dec 2, 2025 · NCT02567136Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05137665Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
RecruitingPhase 3
Ages 18 to 81 · All sexes · Updated Sep 12, 2025 · NCT03127267ALS Research Collaborative
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 20, 2025 · NCT06885918From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.