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Alzheimer's Disease clinical trials in Orlando, FL

25 studies for Alzheimer's Disease are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

RecruitingPhase 3
  • Local Institution - 1635, Orlando
Ages 55 to 90 · All sexes · Updated Sep 28, 2026 · NCT06937229

A Study of LY3439539 in Participants With Alzheimer's Disease

RecruitingPhase 1
  • Charter Research, Orlando
  • AdventHealth Orlando, Orlando
  • K2 Medical Research, Maitland · 6 mi away
Ages 50 to 85 · All sexes · Updated Sep 24, 2026 · NCT07598370

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
  • Charter Research - Orlando, Orlando
  • Conquest Research, Winter Park · 5 mi away
  • K2 Medical Research ORLANDO, Maitland · 6 mi away
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

RecruitingPhase 3
  • Charter Research Orlando, Orlando
  • Nova Psychiatry, Orlando
  • Combined Research Orlando Phase I-IV LLC, Orlando
  • and 1 more
Ages 55 to 90 · All sexes · Updated Sep 22, 2026 · NCT06585787

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

RecruitingPhase 3
  • Charter Research - Winter Park/Orlando, Orlando
  • Conquest Research - Lake Nona, Orlando
  • Conquest Research, LLC, Winter Park · 5 mi away
  • and 2 more
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352

Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

RecruitingPhase 2
  • Conquest Research - Lake Nona, Orlando
Ages 55 to 80 · All sexes · Updated Sep 21, 2026 · NCT06847321

A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease

RecruitingPhase 1/2
  • Conquest Research - Winter Park /ID# 277760, Winter Park · 5 mi away
  • K2 Medical Research - Clermont /ID# 277859, Clermont · 24 mi away
Ages 50 to 90 · All sexes · Updated Sep 18, 2026 · NCT07599670

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

RecruitingPhase 3
  • Local Institution - 2634, Orlando
Ages 55 to 90 · All sexes · Updated Sep 16, 2026 · NCT07011745

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

RecruitingPhase 3
  • Combined Research Orlando (CRO), Orlando
  • Local Institution - 1622, Maitland · 6 mi away
  • Local Institution - 1631, Maitland · 6 mi away
Ages 55 to 90 · All sexes · Updated Sep 16, 2026 · NCT07011732

A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease

RecruitingPhase 3
  • K2 Medical Research, LLC, Maitland · 6 mi away
Ages 55 to 80 · All sexes · Updated Sep 10, 2026 · NCT07717411

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

RecruitingPhase 2
  • ClinCloud, Maitland · 6 mi away
  • Local Institution - 0007, Maitland · 6 mi away
Ages 55 to 90 · All sexes · Updated Sep 1, 2026 · NCT06808984

A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease

RecruitingPhase 2
  • K2 Medical Research, Maitland · 6 mi away
Ages 55 and older · All sexes · Updated Aug 31, 2026 · NCT06540833

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

RecruitingPhase 2
  • Clinical Site, Orlando
Ages 55 to 90 · All sexes · Updated Aug 27, 2026 · NCT06887192

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

RecruitingPhase 2
  • Charter Research - Orlando ( Site 1051), Orlando
  • Conquest Research LLC ( Site 1053), Winter Park · 5 mi away
  • K2 Medical Research ( Site 1047), Maitland · 6 mi away
Ages 50 to 85 · All sexes · Updated Aug 26, 2026 · NCT07033494

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

RecruitingPhase 1
  • K2 Medical Research, LLC, Maitland · 6 mi away
Ages 50 to 85 · All sexes · Updated Aug 24, 2026 · NCT06297590

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

RecruitingPhase 1/2
  • Charter Research, LLC, Orlando
  • Headlands Horizons LLC, Orlando
Ages 35 to 85 · All sexes · Updated Jul 10, 2026 · NCT05462106

Low-Dose Radiotherapy for Alzheimer's Disease

RecruitingPhase 1/2
  • Renaissance Institute of Precision Oncology & Radiosurgery, Winter Park · 5 mi away
Ages 50 and older · All sexes · Updated Jul 9, 2026 · NCT07693140

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

RecruitingPhase 3
  • Charter Research - Orlando, Orlando
  • Headlands Research Orlando, Orlando
  • Conquest Research, Winter Park · 5 mi away
  • and 1 more
Ages 55 and older · All sexes · Updated Jul 7, 2026 · NCT07602582

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

RecruitingPhase 2
  • Conquest Research, Winter Park · 5 mi away
  • K2 Medical Research LLC, Maitland · 6 mi away
  • K2 Medical Research LLC, Maitland · 6 mi away
Ages 50 to 85 · All sexes · Updated Jun 26, 2026 · NCT07094516

A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

RecruitingPhase 1Healthy volunteers welcome
  • K2 Medical Research, Maitland · 6 mi away
Ages 45 to 85 · All sexes · Updated Jun 4, 2026 · NCT06657768

[18F]PI-2620 Phase 3 Histopathological Study

RecruitingPhase 3
  • Charter Research, Winter Park · 5 mi away
  • K2 Medical Research, Maitland · 6 mi away
Ages 50 and older · All sexes · Updated May 22, 2026 · NCT05641688

Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

RecruitingObservational studyHealthy volunteers welcome
  • Charter Research, Orlando
  • Conquest Research, Winter Park · 5 mi away
  • K2 Medical Research, Maitland · 6 mi away
  • and 1 more
Ages 60 to 90 · All sexes · Updated Apr 15, 2026 · NCT06584357

Open-label Extension Study in Participants With Early Alzheimer's Disease

RecruitingPhase 2
  • GSK Investigational Site, Maitland · 6 mi away
Ages 50 to 85 · All sexes · Updated Feb 2, 2026 · NCT07105709

ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease

Recruiting
  • Advent Health, Orlando
Ages 50 to 85 · All sexes · Updated Jan 9, 2026 · NCT03671889

University of Central Florida CereBank

RecruitingObservational studyHealthy volunteers welcome
  • University of Central Florida, Orlando
Ages 18 and older · Women · Updated Mar 14, 2025 · NCT06876857

About Alzheimer's Disease

Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills. It's the most common cause of dementia among older adults.

More about Alzheimer's Disease on MedlinePlus

Alzheimer's Disease trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.