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Depression clinical trials in California
67 studies for Depression are looking for participants at sites in California.
Cities in California
- San Diego18 studies
- Los Angeles17 studies
- San Francisco15 studies
- Mountain View9 studies
- Orange8 studies
- San Bernardino5 studies
- Concord5 studies
- Sacramento5 studies
- Chino5 studies
- Irvine4 studies
- Glendale4 studies
- Costa Mesa3 studies
- Bellflower3 studies
- Oceanside3 studies
- Santa Monica3 studies
- Oakland3 studies
- San Jose3 studies
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Behavioral Research Specialists, LLC, Glendale
- CalNeuro Research Group, Los Angeles
- Lipov Medical Group, Los Angeles
- and 4 more
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
- Kadima Neuropsychiatry Institute, San Diego
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Chino
- Seaport Investigator Site, Garden Grove
- Seaport Investigator Site, Glendale
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- ATP Clinical Research, Inc., Costa Mesa
- Salma Health, La Jolla
- Keck Hospital of USC, Los Angeles
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT03887715E-Mindfulness Approaches for Living After Breast Cancer
- Kaiser Permanente-Anaheim, Anaheim
- Kaiser Permanente-Deer Valley Medical Center, Antioch
- AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
- and 56 more
RecruitingPhase 3
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Accellacare - Moorpark, Moorpark
- ATP Clinical Research, Orange
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
- Irvine Clinical Research, Irvine
- Healthy Brain Clinic, Long Beach
- Oakland Clinical, Oakland
- and 1 more
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
- Children's Hospital of Orange County, Orange
RecruitingObservational study
18 Months – 11 Years · All sexes · Updated Nov 3, 2026 · NCT07048574Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Chino
- Neurocrine Clinical Site, Glendale
- Neurocrine Clinical Site, Irvine
- and 6 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06966401A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Clinical Research Site, Buena Park
- Clinical Research Site, Chino
- Clinical Research Site, Lemon Grove
- and 3 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07621237Focused Ultrasound for Behavioral Health
- Attune Neurosciences, Inc., San Francisco
- Attune, San Francisco Clinical Research Center, San Francisco
Recruiting
Ages 22 to 80 · All sexes · Updated Oct 27, 2026 · NCT07851038Morphine or Ketamine for Analgesia
- Children's Hospital Los Angeles, Los Angeles
- UC Davis Children's Hospital, Sacramento
RecruitingPhase 3
Ages 6 to 17 · All sexes · Updated Oct 20, 2026 · NCT06835504Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)
- San Diego State University, San Diego
Recruiting
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06753123Training Reward Responsiveness Through Virtual Reality
- University of California, Los Angeles, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07219875A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Bellflower
- Draig Clinical Site, Costa Mesa
- Draig Clinical Site, Lafayette
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473Meditative Neurofeedback for Depression
- University of California San Diego, La Jolla
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT06675240A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Oceanside
- Draig Clinical Site, San Diego
- Draig Clinical Site, Torrance
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 8, 2026 · NCT07300969Brexanolone Lifting Outcomes Of Moms
- Lipocine Investigational Site, Canoga Park
- Lipocine Investigational Site, Walnut Creek
RecruitingPhase 3
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321Near Infrared Spectroscopy (NIRS) for Assessment of Depression
- San Francisco Veterans Affairs Medical Center, San Francisco
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04061148Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression
- Stanford University, Stanford
Recruiting
Ages 65 and older · All sexes · Updated Aug 21, 2026 · NCT07188623Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
- VA San Diego Healthcare System, San Diego, CA, San Diego
Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06162741Cognitive Training as an Adjunct to Ketamine in Real-world Clinics
- Kaiser Foundation Research Institute, a division of Kaiser Foundation Hospitals, Oakland
Recruiting
Ages 18 to 80 · All sexes · Updated Aug 19, 2026 · NCT06526078Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
- Stanford Hospital, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Aug 11, 2026 · NCT04870255NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Glendale
- Neurocrine Clinical Site, Redlands
- Neurocrine Clinical Site, San Francisco
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Chino
- Neurocrine Clinical Site, Los Angeles
- Neurocrine Clinical Site, Stanford
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021Psilocybin Therapy for Depression in Parkinson's Disease
- University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 40 to 80 · All sexes · Updated Aug 7, 2026 · NCT06455293Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
- University of California San Diego Hillcrest Medical Center, San Diego
Recruiting
Ages 45 to 75 · Women · Updated Aug 5, 2026 · NCT06678880Closed-Loop Deep Brain Stimulation for Major Depression
- University of California, San Francisco, San Francisco
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 3, 2026 · NCT04004169Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease
- University of California Davis Health System, Sacramento
Recruiting
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT07717723A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
- Advanced Research Center /ID# 227073, Anaheim
- Inland Pyschiatric Medical Group - Chino /ID# 278667, Chino
- Accellacare - Long Beach /ID# 279482, Long Beach
- and 4 more
RecruitingPhase 3
Ages 10 to 17 · All sexes · Updated Jul 27, 2026 · NCT04777357Cognition and Behavior With Sham Accelerated TMS
- UC Davis Medical Center, Sacramento
Recruiting
Ages 15 to 25 · All sexes · Updated Jul 16, 2026 · NCT07397858Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
- Acacia Clinics, Sunnyvale
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jul 16, 2026 · NCT06376734Probiotic Administration for Adolescent Depression
- UCSF, San Francisco
RecruitingEarly phase 1
Ages 15 to 24 · All sexes · Updated Jul 14, 2026 · NCT06898788Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study
- University of California, Los Angeles, Los Angeles
Recruiting
Ages 18 and older · Women · Updated Jul 6, 2026 · NCT07577947fMRI Neurofeedback With Matter Neuroscience App
- Stanford University Brain Stimulation Lab, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Jul 6, 2026 · NCT06735885A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
- UCLA Semel Institute - Neuropsychiatric Institute (NPI), Los Angeles
RecruitingEarly phase 1
Ages 50 to 95 · All sexes · Updated Jul 6, 2026 · NCT06906939Phase II: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings
- Ohana Center for Child and Adolescent Behavioral Health, Monterey
- Stanford University, Stanford
Recruiting
Ages 5 to 14 · All sexes · Updated Jun 29, 2026 · NCT07155707Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
- University of California, Los Angeles, Los Angeles
RecruitingObservational study
Ages 14 to 21 · All sexes · Updated May 29, 2026 · NCT05329441Assessing Improvements in Mood and Sleep Trial
- The Regents of the University of California, Los Angeles, Los Angeles
Recruiting
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT06639477Better Sleep Study
- Children's Hospital Los Angeles, Los Angeles
Recruiting
Ages 12 to 18 · All sexes · Updated May 11, 2026 · NCT06139861From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.