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Depression clinical trials in Orange, CA

9 studies for Depression are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • ATP Clinical Research, Orange
  • NRC Research Institute, Orange
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Nrc Research Institute, Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • ATP Clinical Research, Orange
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Atp Clinical Research, Orange
  • Nrc Research Institute, Orange
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Orange
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

RecruitingObservational study
  • Children's Hospital of Orange County, Orange
18 Months – 11 Years · All sexes · Updated Jul 6, 2026 · NCT07048574

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Orange
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.