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Depression clinical trials in San Francisco, CA

15 studies for Depression are looking for participants at sites in and around San Francisco (within about 30 miles). Open a study to see who can join and how to contact the study team.

Near Infrared Spectroscopy (NIRS) for Assessment of Depression

RecruitingHealthy volunteers welcome
  • San Francisco Veterans Affairs Medical Center, San Francisco
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04061148

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Francisco
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

Psilocybin Therapy for Depression in Parkinson's Disease

RecruitingPhase 2
  • University of California, San Francisco, San Francisco
Ages 40 to 80 · All sexes · Updated Aug 7, 2026 · NCT06455293

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Kaiser Permanente-San Francisco, San Francisco
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

Closed-Loop Deep Brain Stimulation for Major Depression

Recruiting
  • University of California, San Francisco, San Francisco
Ages 22 to 70 · All sexes · Updated Aug 3, 2026 · NCT04004169

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Francisco
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Probiotic Administration for Adolescent Depression

RecruitingEarly phase 1
  • UCSF, San Francisco
Ages 15 to 24 · All sexes · Updated Jul 14, 2026 · NCT06898788

Ketamine for Veterans With Parkinson's Disease

RecruitingPhase 2
  • San Francisco VA Medical Center, San Francisco, CA, San Francisco
Ages 40 to 80 · All sexes · Updated Apr 13, 2026 · NCT06231563

Biomarkers of Depression and Treatment Response

Recruiting
  • University of California, San Francisco, San Francisco
Ages 18 to 70 · All sexes · Updated Jan 30, 2026 · NCT04581902

Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

RecruitingObservational study
  • University of California, San Francisco, San Francisco
Ages 65 and older · All sexes · Updated Nov 25, 2025 · NCT02434393

Treating Major Depression With Yoga Mono-therapy

Recruiting
  • Zuckerberg San Francisco General Hospital, San Francisco
Ages 18 and older · All sexes · Updated Nov 6, 2025 · NCT06091527

SUpport From PEeRs to Expand Access Study - Community

Recruiting
  • Zuckerberg San Francisco General, San Francisco
Ages 18 to 100 · All sexes · Updated Sep 22, 2025 · NCT07186816

Model-based Electrical Brain Stimulation

Recruiting
  • University of California, San Francisco, San Francisco
Ages 18 and older · All sexes · Updated Sep 22, 2025 · NCT05327387

Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression

Recruiting
  • University of California, San Francisco, San Francisco
Ages 22 to 70 · All sexes · Updated Aug 17, 2025 · NCT07127913

A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations

Recruiting
  • UCSF Alliance Health Project, San Francisco
Ages 18 and older · All sexes · Updated Apr 24, 2025 · NCT06367764

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in San Francisco

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.