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Depression clinical trials in Illinois
29 studies for Depression are looking for participants at sites in Illinois.
Cities in Illinois
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Rush University, Chicago
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
- Rush University Medical Center, Chicago
- University of Chicago Medical Center, Chicago
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- Rush University Medical Center, Chicago
- AMR- Baber Research, Inc., Naperville
- Psychiatric Medicine Associates, LLC, Skokie
- and 1 more
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT03887715E-Mindfulness Approaches for Living After Breast Cancer
- Northwest Community Hospital, Arlington Heights
- Advocate Outpatient Center - Aurora, Aurora
- Advocate Good Shepherd Hospital, Barrington
- and 55 more
RecruitingPhase 3
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222Our Voices Matter: Intervention for Depression in Youth
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
RecruitingHealthy volunteers welcome
Ages 15 to 20 · All sexes · Updated Nov 4, 2026 · NCT07216326A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
- Charter Research - Chicago, Chicago
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Clinical Research Site, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07621237Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
RecruitingHealthy volunteers welcome
Ages 15 to 20 · All sexes · Updated Oct 22, 2026 · NCT07554326A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Chicago
- Draig Clinical Site, Skokie
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473CommunityRx-Dementia + Peer Navigation (CRxDpeer)
- University of Chicago, Chicago
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT07346183The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis
- University of Illinois Chicago, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT07504120Brexanolone Lifting Outcomes Of Moms
- Lipocine Investigational Site, Chicago
RecruitingPhase 3
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321Cognitive Training as an Adjunct to Ketamine in Real-world Clinics
- University of Illinois at Chicago, Chicago
Recruiting
Ages 18 to 80 · All sexes · Updated Aug 19, 2026 · NCT06526078Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
- Department of Medicine, Vitoux Program on Aging and Prevention, Chicago
Recruiting
Ages 50 to 74 · All sexes · Updated Aug 18, 2026 · NCT06636058Maternal Mindfulness: Depression and Postpartum Pain
- University of Illinois Urbana-Champaign, Champaign
RecruitingHealthy volunteers welcome
Ages 18 to 45 · Women · Updated Aug 6, 2026 · NCT05400382A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
- Advanced Quality Medical Research /ID# 272902, Orland Park
RecruitingPhase 3
Ages 10 to 17 · All sexes · Updated Jul 27, 2026 · NCT04777357Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury
- Northwestern University, Chicago
Recruiting
Ages 14 to 18 · All sexes · Updated Jul 8, 2026 · NCT07224165Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
- University of Illinois College of Medicine, Chicago
RecruitingPhase 2
Ages 60 and older · All sexes · Updated Jun 30, 2026 · NCT06591091Experimental Evidence of the Impact of Parental Income on Child Mental Health and Neuroimmune Function
- Northwestern University, Evanston
Recruiting
Ages 10 to 18 · All sexes · Updated Jun 11, 2026 · NCT07641244Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
- University of Illinois at Chicago, Chicago
Recruiting
Ages 18 to 64 · All sexes · Updated Jun 4, 2026 · NCT05051618My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
- Northwestern University, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT05369429Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
- Northwestern University Feinberg School of Medicine, Chicago
Recruiting
Ages 18 and older · All sexes · Updated May 28, 2026 · NCT07610655Test of Target Engagement of Ambiguity Aversion
- Northwestern University, Chicago
RecruitingHealthy volunteers welcome
Ages 25 to 60 · All sexes · Updated May 26, 2026 · NCT06962527Community-based Approach to Lowering Stress Through Mindfulness
- The Salvation Army Ray and Joan Kroc Corps Community Center Chicago, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06987799ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression
- University of Illinois at Chicago, Chicago
RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Mar 5, 2026 · NCT06408246Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
- University of Illinios Chicago, Chicago
Recruiting
Ages 12 to 55 · All sexes · Updated Oct 1, 2025 · NCT06261463Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
- University of Illinois at Chicago, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Sep 19, 2025 · NCT05094297Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss
- The Chicago Lighthouse, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Jul 30, 2025 · NCT07073521A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
- Clinical Research Site, Chicago
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.