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Depression clinical trials in Chicago, IL
23 studies for Depression are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Rush University, Chicago
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 2
- Chicago Research Center, Chicago
Brexanolone Lifting Outcomes Of Moms
RecruitingPhase 3
- Lipocine Investigational Site, Chicago
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
- Rush University Medical Center, Chicago
- University of Chicago Medical Center, Chicago
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Chicago
Cognitive Training as an Adjunct to Ketamine in Real-world Clinics
Recruiting
- University of Illinois at Chicago, Chicago
Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
Recruiting
- Department of Medicine, Vitoux Program on Aging and Prevention, Chicago
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- Northwestern University, Chicago
- Rush MD Anderson Cancer Center, Chicago
Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury
Recruiting
- Northwestern University, Chicago
Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
RecruitingPhase 2
- University of Illinois College of Medicine, Chicago
Our Voices Matter: Intervention for Depression in Youth
RecruitingHealthy volunteers welcome
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
- Rush University Medical Center, Chicago
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Recruiting
- University of Illinois at Chicago, Chicago
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
Recruiting
- Northwestern University, Chicago
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
Recruiting
- Northwestern University Feinberg School of Medicine, Chicago
Test of Target Engagement of Ambiguity Aversion
RecruitingHealthy volunteers welcome
- Northwestern University, Chicago
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
RecruitingPhase 2
- Pillar Clinical Research LLC, Chicago
Community-based Approach to Lowering Stress Through Mindfulness
Recruiting
- The Salvation Army Ray and Joan Kroc Corps Community Center Chicago, Chicago
ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression
RecruitingPhase 2
- University of Illinois at Chicago, Chicago
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
Recruiting
- University of Illinios Chicago, Chicago
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
Recruiting
- University of Illinois at Chicago, Chicago
Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss
Recruiting
- The Chicago Lighthouse, Chicago
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
RecruitingPhase 4
- Clinical Research Site, Chicago
About Depression
Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.
More about Depression on MedlinePlus
Depression trials in other cities
- Boston, MA51 studies
- New York City, NY46 studies
- Philadelphia, PA24 studies
- Pittsburgh, PA22 studies
- Atlanta, GA22 studies
- San Diego, CA21 studies
- Charleston, SC19 studies
- Houston, TX18 studies
- Los Angeles, CA17 studies
- Orlando, FL17 studies
- Miami, FL16 studies
- Durham, NC15 studies
Other studies in Chicago
- Non-Small Cell Lung Cancer62 studies
- Breast Cancer58 studies
- Cancer (all types)52 studies
- Prostate Cancer45 studies
- Metastatic Cancer45 studies
- Lung Cancer41 studies
- Obesity41 studies
- Ovarian Cancer37 studies
- Stroke35 studies
- Heart Failure32 studies
- Colorectal Cancer32 studies
- Overweight27 studies
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.