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Glioblastoma clinical trials in Durham, NC

20 studies for Glioblastoma are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

RecruitingPhase 3
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05902169

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Duke University Health System, Durham
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Duke University Health System, Durham
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

RecruitingPhase 2
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06319027

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT04903795

A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

RecruitingPhase 2
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT05708352

A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

RecruitingPhase 2
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06069726

Lerapolturev (PVSRIPO) in GBM

RecruitingPhase 2
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT06177964

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

RecruitingPhase 2
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT06805305

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Duke University Health System, Durham
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04547777

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Duke University Health System, Durham
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT05366179

Key Longitudinal Associations With Risk and Glioblastoma Outcomes

RecruitingObservational study
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06625684

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

D2C7-IT + 2141-V11 Combination Post-resection in rGBM

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Oct 23, 2025 · NCT06455605

D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

RecruitingPhase 1/2
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Oct 6, 2025 · NCT05734560

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

RecruitingPhase 2
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 27, 2025 · NCT03175224

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

RecruitingPhase 1
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Jun 25, 2025 · NCT05879367

Glioblastoma trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.