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Glioblastoma clinical trials in Columbus, OH

14 studies for Glioblastoma are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

RecruitingPhase 1/2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05432804

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07326566

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

RecruitingPhase 3
  • The Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07195591

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Nationwide Children's Hospital, Columbus
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

RecruitingPhase 1
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06860594

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Nationwide Children's Hospital, Columbus
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

Recruiting
  • Ohio State University Medical Center, Columbus
Ages 18 to 85 · All sexes · Updated Jul 21, 2026 · NCT06910306

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

RecruitingPhase 2
  • Ohio State University, Columbus
Ages 18 to 80 · All sexes · Updated Jul 17, 2026 · NCT07225621

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

RecruitingPhase 2
  • The Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT06805305

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Nationwide Children's Hospital, Columbus
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

RecruitingPhase 1/2
  • Ohio State University Hospital, Columbus
Ages 18 to 70 · All sexes · Updated Jun 12, 2026 · NCT07346144

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Nationwide Children's Hospital, Columbus
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06810544

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Columbus
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Glioblastoma trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.