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Glioblastoma clinical trials in Chicago, IL

15 studies for Glioblastoma are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

RecruitingPhase 1/2
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05432804

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

RecruitingPhase 3
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05902169

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

RecruitingPhase 1
  • Northwestern Univerity, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05303467

Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma

RecruitingPhase 1
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06410248

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

RecruitingPhase 1
  • Northwestern University, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06860594

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

RecruitingPhase 1
  • Northwestern Medicine, Chicago
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT07464925

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05879250

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
  • Northwestern Memorial Hospital, Chicago
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06810544

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Glioblastoma trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.