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Head and Neck Squamous Cell Carcinoma clinical trials in Springfield, IL

6 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Springfield (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • Southern Illinois University School of Medicine, Springfield
  • Springfield Clinic, Springfield
  • Springfield Memorial Hospital, Springfield
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06589804

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Southern Illinois University School of Medicine, Springfield
  • Springfield Clinic, Springfield
  • Springfield Memorial Hospital, Springfield
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

RecruitingPhase 2
  • Southern Illinois University School of Medicine, Springfield
  • Springfield Clinic, Springfield
  • Springfield Memorial Hospital, Springfield
Ages 18 to 79 · All sexes · Updated Sep 22, 2026 · NCT04671667

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Southern Illinois University School of Medicine, Springfield
  • Springfield Clinic, Springfield
  • Springfield Memorial Hospital, Springfield
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Southern Illinois University - Simmons Cancer Institute, Springfield
  • Springfield Clinic Radiology - 800 Building, Springfield
  • Springfield Clinic Urgent Care Plus, Springfield
  • and 4 more
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

RecruitingPhase 3
  • Southern Illinois University School of Medicine, Springfield
  • Springfield Clinic, Springfield
  • Springfield Memorial Hospital, Springfield
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT06992427

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Springfield

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.