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HIV clinical trials in Chicago, IL

14 studies for HIV are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

RecruitingPhase 2/3
  • Rush University Medical Center-Infectious Disease ( Site 1522), Chicago
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07266831

Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention

RecruitingObservational study
  • DOM/Project WISH Research Clinic, Chicago
  • Rush University Medical Center/Division of Infectious Diseases, Chicago
  • Ruth M. Rothstein CORE Center, Chicago
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07473778

Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission

RecruitingPhase 1/2
  • 32515, Rush Univ./Cook County Hosp. Chicago CRS, Chicago
  • 4001, Lurie Children's Hospital of Chicago Clinical Research Site, Chicago
48 Hours · All sexes · Updated Sep 9, 2026 · NCT02140255

Dasatinib for HIV-1 Reservoir Reduction

RecruitingPhase 1
  • Northwestern University CRS (Site # 2701), Chicago
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT07342491

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

RecruitingPhase 2
  • GSK Investigational Site, Chicago
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07202546

The Trans-Led Care Study

Recruiting
  • Illinois Institute of Technology, Chicago
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06880705

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

RecruitingPhase 1
  • University of Illinois at Chicago, Chicago
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05077527

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Recruiting
  • Northwestern University, Chicago
  • Rush University Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06263426

Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

RecruitingHealthy volunteers welcome
  • Ali Keshavarzian, Chicago
Ages 45 to 75 · All sexes · Updated Jun 4, 2026 · NCT06139224

Menopausal HT for Women Living With HIV (HoT)

RecruitingPhase 4
  • Northwestern University CRS (2701), Chicago
Ages 40 to 60 · Women · Updated May 22, 2026 · NCT06856174

Effectiveness of Relationship Education for Reducing HIV Incidence Among Men Who Have Sex With Men

RecruitingHealthy volunteers welcome
  • Northwestern University, Chicago
Ages 16 to 34 · All sexes · Updated May 8, 2026 · NCT05678556

IMARA for Black Male Caregivers and Girls Empowerment (IMAGE)

RecruitingHealthy volunteers welcome
  • University of Illinois Chicago, Chicago
Ages 13 and older · All sexes · Updated Apr 17, 2026 · NCT06266416

MyPEEPS LITE Trial

RecruitingHealthy volunteers welcome
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Ages 16 to 29 · Men · Updated Feb 27, 2026 · NCT06741631

Keeping it LITE: Exploring HIV Risk in Vulnerable Youth With Limited Interaction and Digital Health Intervention

RecruitingObservational studyHealthy volunteers welcome
  • John H. Stroger, Jr. Hospital of Cook County, Chicago
Ages 13 to 34 · All sexes · Updated May 8, 2023 · NCT05848570

About HIV

HIV (human immunodeficiency virus) attacks the body’s immune system. There is no cure but it can be treated with medicines. To know if you have HIV, get tested.

More about HIV on MedlinePlus

HIV trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.