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Long COVID clinical trials in Chicago, IL

12 studies for Long COVID are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1283 in Participants ≥6 Months to <12 Years of Age

RecruitingPhase 2Healthy volunteers welcome
  • Eagle Clinical Research, LLC, Chicago
6 Months – 11 Years · All sexes · Updated Nov 9, 2026 · NCT07808697

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

RecruitingPhase 3
  • Rush University Medical Center ( Site 3748), Chicago
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06667700

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

RecruitingPhase 3
  • University of Illinois Health, Chicago
28 Days · All sexes · Updated Nov 4, 2026 · NCT02735707

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

RecruitingPhase 3
  • Northwestern Memorial Hospital, Chicago
  • Northwestern University Feinberg School of Medicine, Chicago
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT07013474

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

RecruitingPhase 3
  • Illinois Research Network (ILLInet), University of Illinois Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06631287

Dime La VerDAD: Verify, Debunk, and Disseminate

RecruitingHealthy volunteers welcome
  • University of Chicago, Chicago
Ages 18 to 99 · All sexes · Updated Aug 26, 2026 · NCT06417762

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

RecruitingPhase 3
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
All ages · All sexes · Updated Jun 23, 2026 · NCT03808922

Cognitive-Sensorimotor Function in Long-COVID

RecruitingObservational studyHealthy volunteers welcome
  • Jesse Brown VA Medical Center, Chicago, IL, Chicago
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT06850350

Dysbiosis & Long COVID

RecruitingObservational studyHealthy volunteers welcome
  • The University of Chicago, Chicago
Ages 18 to 80 · All sexes · Updated Mar 2, 2026 · NCT06825819

A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection

RecruitingPhase 4Healthy volunteers welcome
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT06008860

Convalescent Plasma as a Possible Treatment for COVID-19

RecruitingPhase 2
  • University of Illinois at Chicago, Chicago
Ages 40 and older · All sexes · Updated Jun 22, 2020 · NCT04442191

About Long COVID

Anyone who has had COVID-19 can have long-lasting symptoms, know as long COVID. Learn about the symptoms and how to manage them, diagnosis, and prevention.

More about Long COVID on MedlinePlus

Long COVID trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.