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Lung Cancer clinical trials in Irvine, CA
15 studies for Lung Cancer are looking for participants at sites in and around Irvine (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
RecruitingPhase 3
- Kaiser Permanente-Irvine, Irvine
Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer
RecruitingPhase 2
- City of Hope Lennar Foundation Cancer Center, Irvine
A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- The City of Hope Orange County Lennar Foundation Cancer Center, Irvine
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
RecruitingPhase 2/3
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care building, Irvine
Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Recruiting
- CHAO Family Comprehensive Cancer Center- Irvine, Irvine
- UCI Health Gottschalk Medical Plaza, Irvine
Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer
RecruitingPhase 1/2
- City of Hope at Irvine Lennar, Irvine
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
RecruitingPhase 3
- UCI Health-CIACC, Irvine
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
RecruitingPhase 1/2
- City of Hope - Lennar, Irvine
Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2/3
- City of Hope at Irvine Lennar, Irvine
- Kaiser Permanente-Irvine, Irvine
Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
RecruitingPhase 1/2
- University of California, Irvine, Irvine
Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer
RecruitingPhase 1
- City of Hope at Irvine Lennar, Irvine
Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers
RecruitingHealthy volunteers welcome
- City of Hope at Irvine Lennar, Irvine
Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Irvine
About Lung Cancer
Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.
More about Lung Cancer on MedlinePlus
Lung Cancer trials in other cities
- Houston, TX78 studies
- Boston, MA62 studies
- New York City, NY60 studies
- Los Angeles, CA45 studies
- Washington, DC41 studies
- Chicago, IL41 studies
- Nashville, TN40 studies
- Arlington, VA40 studies
- Baltimore, MD40 studies
- St. Louis, MO39 studies
- Columbus, OH36 studies
- Philadelphia, PA36 studies
Other studies in Irvine
- Non-Small Cell Lung Cancer25 studies
- Breast Cancer23 studies
- Cancer (all types)17 studies
- Metastatic Cancer16 studies
- Prostate Cancer14 studies
- Multiple Myeloma13 studies
- Ovarian Cancer12 studies
- Alzheimer's Disease11 studies
- Head and Neck Squamous Cell Carcinoma11 studies
- Bladder Cancer11 studies
- Pancreatic Cancer10 studies
- Endometrial Cancer10 studies
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.