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Major Depressive Disorder clinical trials in Washington, DC

11 studies for Major Depressive Disorder are looking for participants at sites in and around Washington (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

RecruitingPhase 2
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Oct 5, 2026 · NCT06511908

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

RecruitingObservational studyHealthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 8 to 70 · All sexes · Updated Oct 2, 2026 · NCT05669703

Natural History of Depression, Bipolar Disorder and Suicide Risk

RecruitingObservational study
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 120 · All sexes · Updated Oct 1, 2026 · NCT06462196

Characterization and Treatment of Adolescent Depression

RecruitingObservational studyHealthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 11 to 25 · All sexes · Updated Sep 28, 2026 · NCT03388606

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • Children's National Medical Center, Washington D.C.
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

RecruitingPhase 1Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT03065335

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

RecruitingPhase 2Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
  • University of Maryland, College Park, College Park · 8 mi away
Ages 8 to 65 · All sexes · Updated Sep 22, 2026 · NCT00018057

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

RecruitingPhase 1
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Sep 10, 2026 · NCT03973268

Neurobiology of Suicide

RecruitingPhase 2Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT02543983

Mindful Self-Compassion for Anxiety Disorders and Depression

Recruiting
  • Georgetown University Medical Center, Washington D.C.
Ages 18 to 75 · All sexes · Updated Jul 29, 2026 · NCT05671419

Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

Recruiting
  • Georgetown University Medical Center, Washington D.C.
Ages 18 to 65 · All sexes · Updated May 5, 2026 · NCT07028216

Major Depressive Disorder trials in other cities

Other studies in Washington

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.