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Major Depressive Disorder clinical trials in O'Fallon, MO

8 studies for Major Depressive Disorder are looking for participants at sites in and around O'Fallon (within about 30 miles). Open a study to see who can join and how to contact the study team.

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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
  • St. Charles Psychiatric Associates, Inc. dba Midwest Research Group, Saint Charles · 12 mi away
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT07284667

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

RecruitingPhase 3
  • Psychiatric Care and Research Center (PCRC), O'Fallon
Ages 18 to 65 · All sexes · Updated Nov 3, 2026 · NCT05850689

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, O'Fallon
  • Neurocrine Clinical Site, Saint Charles · 12 mi away
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06966401

Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

RecruitingPhase 2
  • Psychiatric Care and Research Center, O'Fallon
  • Midwest Research Group, Saint Charles · 12 mi away
Ages 18 to 70 · All sexes · Updated Oct 28, 2026 · NCT07226661

A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, O'Fallon
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07196501

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, Saint Charles · 12 mi away
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #127, Saint Charles · 12 mi away
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Saint Charles · 12 mi away
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Major Depressive Disorder trials in other cities

Other studies in O'Fallon

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.