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Depression clinical trials in O'Fallon, MO

5 studies for Depression are looking for participants at sites in and around O'Fallon (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Psychiatric Care and Research Center, O'Fallon
  • St. Charles Psychiatric Associates - Midwest Research Group, Saint Charles · 12 mi away
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, O'Fallon
  • Neurocrine Clinical Site, Saint Charles · 12 mi away
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Midwest Research Group, Saint Charles · 12 mi away
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Saint Charles · 12 mi away
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

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Other studies in O'Fallon

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.