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Melanoma clinical trials in Chicago, IL

15 studies for Melanoma are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Northwestern University, Chicago
  • University of Illinois, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • University of Illinois Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • Northwestern University, Chicago
  • Swedish Covenant Hospital, Chicago
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mount Sinai Hospital Medical Center, Chicago
  • John H Stroger Jr Hospital of Cook County, Chicago
  • University of Illinois, Chicago
  • and 1 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

RecruitingPhase 1/2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05896839

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Lurie Children's Hospital-Chicago, Chicago
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Lurie Children's Hospital-Chicago, Chicago
  • Northwestern University, Chicago
  • University of Illinois, Chicago
  • and 1 more
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

Sun Exposure and Activities After Skin Cancer: Optimization of mHealth Interventions

Recruiting
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT07556380

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

RecruitingPhase 1/2
  • Call for Information (Investigational Site 0024), Chicago
6 Months – 17 Years · All sexes · Updated Jul 6, 2026 · NCT02332668

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

RecruitingPhase 1/2
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT03686124

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

RecruitingPhase 2/3
  • Northwestern Memorial Hospital, Chicago
  • University of Chicago Medical Center, Chicago
All ages · All sexes · Updated Apr 2, 2026 · NCT06581406

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • John H Stroger Jr Hospital of Cook County, Chicago
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.