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Melanoma clinical trials in Cincinnati, OH

17 studies for Melanoma are looking for participants at sites in and around Cincinnati (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • Oncology Hematology Care Clinical Trials, Cincinnati
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

RecruitingPhase 3
  • Oncology Hematology Care, Cincinnati
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT05727904

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Bethesda North Hospital, Cincinnati
  • TriHealth Cancer Institute-Westside, Cincinnati
  • and 1 more
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

RecruitingPhase 2
  • Oncology Hematology Care Inc-Kenwood, Cincinnati
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07287917

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Oncology Hematology Care Inc-Kenwood, Cincinnati
  • Bethesda North Hospital, Cincinnati
  • and 3 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Cincinnati Children's Hospital Medical Center, Cincinnati
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Cincinnati Children's Hospital Medical Center, Cincinnati
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Cincinnati Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT06425926

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

RecruitingPhase 1/2
  • University of Cincinnati Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT03947385

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Christ Hospital Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

Recruiting
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 and older · All sexes · Updated Feb 27, 2026 · NCT07225036

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

RecruitingPhase 3
  • St Elizabeth Healthcare (St Elizabeth Medical Center), Edgewood · 8 mi away
  • St Elizabeth Healthcare (St Elizabeth Medical, Edgewood · 8 mi away
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 113, Cincinnati
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Cincinnati
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • University of Cincinnati, Cincinnati
  • West Chester Hospital (OH394), West Chester · 15 mi away
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Cincinnati

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.