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Melanoma clinical trials in Seattle, WA

17 studies for Melanoma are looking for participants at sites in and around Seattle (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

RecruitingPhase 2
  • Fred Hutchinson Cancer Center ( Site 4041), Seattle
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06961006

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • Swedish Cancer Institute, Seattle
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • Fred Hutchinson Cancer Center, Seattle
  • University of Washington Medical Center - Montlake, Seattle
  • Saint Joseph Medical Center Hematology and Oncology - Silverdale, Silverdale · 17 mi away
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

RecruitingPhase 1/2
  • University of Washington Fred Hutchinson Cancer Center, Seattle
Ages 18 to 99 · All sexes · Updated Sep 22, 2026 · NCT06814496

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

RecruitingPhase 2
  • Local Institution - 0086, Seattle
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07492680

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

RecruitingPhase 2
  • Swedish Medical Center-Ballard Campus, Seattle
  • Swedish Medical Center-Cherry Hill, Seattle
  • Swedish Medical Center-First Hill, Seattle
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Swedish Medical Center-Ballard Campus, Seattle
  • Swedish Medical Center-Cherry Hill, Seattle
  • Swedish Medical Center-First Hill, Seattle
  • and 1 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Seattle Children's Hospital, Seattle
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

Recruiting
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06298734

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

RecruitingPhase 1
  • Fred Hutch/University of Washington Cancer Consortium, Seattle
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05098210

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Virginia Mason Medical Center, Seattle
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

RecruitingPhase 1/2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT03686124

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Kaiser Permanente Washington, Seattle
  • Swedish Medical Center-First Hill, Seattle
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

RecruitingPhase 3
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Seattle
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study of IBI363 in Subjects with Advanced Solid Malignancies

RecruitingPhase 2
  • Fred Hutchinson Cancer Center, Seattle
Ages 18 and older · All sexes · Updated Dec 19, 2024 · NCT06281678

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Seattle

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.