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Metastatic Cancer clinical trials in Jacksonville, FL

28 studies for Metastatic Cancer are looking for participants at sites in and around Jacksonville (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

RecruitingPhase 1
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Mayo Clinic Pharmacy, Jacksonville
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Mayo Clinic in Florida, Jacksonville
All ages · All sexes · Updated Sep 28, 2026 · NCT05564377

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • Mayo Clinic Pharmacy, Jacksonville
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Cancer Specialists of North Florida, Jacksonville
  • Cancer Specialists of North Florida, Jacksonville
  • Cancer Specialists of North Florida, Jacksonville
  • and 4 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

RecruitingPhase 1
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06911008

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • Baptist MD Anderson Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Study of Nuzefatide Pevedotin (BT5528) in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

RecruitingPhase 2
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07450859

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

RecruitingPhase 2/3
  • Mayo Clinic - Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06943755

A Study of KK2269 in Adult Participants With Solid Tumors

RecruitingPhase 1
  • Mayo Clinic Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06266299

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

RecruitingPhase 1
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT04585958

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • University of Florida - Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

RecruitingPhase 1
  • Mayo Clinic - Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • Mayo Clinic Florida-Comprehensive Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic in Florida, Jacksonville
Ages 16 and older · All sexes · Updated Aug 20, 2026 · NCT05269381

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic (Florida), Jacksonville
  • Cancer Specialists of North Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma

RecruitingPhase 2/3
  • Mayo Clinic Comprehensive Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Apr 17, 2026 · NCT06947928

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

RecruitingPhase 2
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT05222620

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

RecruitingObservational study
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Mar 12, 2026 · NCT06349642

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

RecruitingPhase 3
  • Mayo Clinic - Jacksonville, Fl, Jacksonville
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT06127407

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Jacksonville
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Aug 17, 2025 · NCT05394103

Metastatic Cancer trials in other cities

Other studies in Jacksonville

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.