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Breast Cancer clinical trials in Jacksonville, FL

40 studies for Breast Cancer are looking for participants at sites in and around Jacksonville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

RecruitingPhase 3
  • University of Florida Proton Therapy Institute, Jacksonville
Ages 19 and older · Women · Updated Sep 29, 2026 · NCT05856773

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Jacksonville
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

Recruiting
  • Baptist MD Anderson Cancer Center, Jacksonville
Ages 30 and older · Women · Updated Sep 25, 2026 · NCT02945579

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • Mayo Clinic Hospital ( Site 0013), Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Recruiting
  • Baptist MD Anderson, Jacksonville
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07214532

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

Identifying Patterns in the Breath of Individuals With Breast Cancer

RecruitingObservational studyHealthy volunteers welcome
  • Mayo Clinic Breast Clinic, Jacksonville
Ages 40 to 74 · Women · Updated Sep 18, 2026 · NCT06512350

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

RecruitingPhase 1
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT05307705

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

RecruitingPhase 2
  • Cancer Specialists of North Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07405801

To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

RecruitingPhase 2
  • Cancer Specialists of North Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07368998

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT05315700

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • Mayo Clinic Florida-Comprehensive Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Baptist MD Anderson Cancer Center, Jacksonville
  • Mayo Clinic in Florida, Jacksonville
  • Baptist Medical Center South, Jacksonville
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk

RecruitingObservational studyHealthy volunteers welcome
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 100 · Women · Updated Aug 27, 2026 · NCT07207564

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

RecruitingPhase 2Healthy volunteers welcome
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 45 · Women · Updated Aug 20, 2026 · NCT05557877

TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

RecruitingObservational study
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT05507879

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • Mayo Clinic Jacksonville, Jacksonville
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • Mayo Clinic Florida, Jacksonville
  • Cancer Specialists of North Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT06369285

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic - Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

RecruitingPhase 3
  • Mayo Clinic - Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT05696626

Phase 1 Study of CLR 125 in Triple Negative Breast Cancer

RecruitingPhase 1
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT07311993

Intravital Microscopy in Human Solid Tumors

Recruiting
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT03823144

Postoperative Outcomes and Patient Satisfaction With Mayo Clinic Florida Care Hotel After Mastectomy and Tissue Expander Placement

RecruitingObservational study
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · Women · Updated Jun 2, 2026 · NCT06783179

DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Breast Cancer Patients

RecruitingObservational study
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · Women · Updated Jun 1, 2026 · NCT06388122

A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials

RecruitingObservational studyHealthy volunteers welcome
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 100 · All sexes · Updated May 8, 2026 · NCT05655494

Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer

RecruitingObservational study
  • Baptist - MD Anderson Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT00477100

Cancer Genetic Testing in Ethnic Populations

Recruiting
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Apr 2, 2026 · NCT04475640

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Recruiting
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Apr 2, 2026 · NCT05746325

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Jacksonville
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #15, Jacksonville
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • Baptist MD Anderson Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Jacksonville

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.