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Multiple Sclerosis clinical trials in St. Louis, MO

8 studies for Multiple Sclerosis are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
  • Siteman Cancer Center-South County, St Louis
  • Siteman Cancer Center at Christian Hospital, St Louis
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

RecruitingPhase 1/2
  • Washington University, St. Louis, St Louis
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT07477639

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT06782490

An Open-label Study of AZD0120 in Adults With Multiple Sclerosis

RecruitingPhase 1
  • Research Site, St Louis
Ages 18 to 60 · All sexes · Updated Aug 25, 2026 · NCT07224373

Brain Imaging and Immune Changes During Remibrutinib Treatment in Multiple Sclerosis.

RecruitingObservational study
  • Washington University School of Medicine in St. Louis, St Louis
Ages 40 to 70 · All sexes · Updated Aug 11, 2026 · NCT07758270

A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

RecruitingPhase 2
  • Washington University School of Medicine Neurology Clinical Unit, St Louis
Ages 18 to 55 · All sexes · Updated Jun 15, 2026 · NCT06735248

Smoldering Inflammation in MS

RecruitingObservational study
  • Barnes Jewish Center for Clinical Imaging Research, St Louis
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT06591429

About Multiple Sclerosis

Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.

More about Multiple Sclerosis on MedlinePlus

Multiple Sclerosis trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.