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Multiple Sclerosis clinical trials in Chicago, IL

15 studies for Multiple Sclerosis are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

RecruitingObservational study
  • TG Therapeutics Investigational Trial Site, Chicago
  • TG Therapeutics Investigational Trial Site, Chicago
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06433752

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Rush University Medical Center, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

RecruitingPhase 3
  • University of Chicago Medical Center, Chicago
Ages 10 to 17 · All sexes · Updated Sep 10, 2026 · NCT06408259

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

RecruitingPhase 3
  • Northwestern Memorial Hospital, Chicago
Ages 18 to 65 · All sexes · Updated Jul 29, 2026 · NCT07225504

Ocrevus Zunovo for MS: Mixed Methods

RecruitingObservational study
  • Northwestern Memorial Hospital, Chicago
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT07710105

Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT06410261

Functional Balance Intervention in Multiple Sclerosis

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 18 to 90 · All sexes · Updated Jul 6, 2026 · NCT06341023

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 18 to 64 · All sexes · Updated Jun 4, 2026 · NCT05051618

Nomad P-KAFO Study

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 to 89 · All sexes · Updated May 11, 2026 · NCT05644522

Intermittent Hypoxia in Persons With Multiple Sclerosis

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 to 75 · All sexes · Updated Mar 20, 2026 · NCT06276634

People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

RecruitingObservational study
  • Northwestern Memorial Hospital, Chicago
Ages 18 to 70 · All sexes · Updated Mar 17, 2026 · NCT07207148

Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis

RecruitingPhase 4
  • Northwestern Memorial Hospital, Chicago
Ages 18 to 70 · All sexes · Updated Mar 17, 2026 · NCT07225361

Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 to 75 · All sexes · Updated Feb 23, 2026 · NCT06390930

Home Based Functional Balance Intervention for Multiple Sclerosis

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 40 to 90 · All sexes · Updated Jan 21, 2026 · NCT07355387

About Multiple Sclerosis

Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.

More about Multiple Sclerosis on MedlinePlus

Multiple Sclerosis trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.